Strategic innovation in the total synthesis of complex natural products using gold catalysis.

Natural product reports (2014-01-31)
Yun Zhang, Tuoping Luo, Zhen Yang
RESUMO

Novel organic reactions drive the advance of chemical synthesis in the same way that enabling technologies drive new scientific discoveries. One area of organic methodology that has undergone significant growth during the last decade is that of homogeneous gold-catalyzed transformations. This trend has been further enhanced by the employment of gold catalysis on a routine basis to accomplish the total synthesis of natural products. In particular, the superior π acidity of the cationic gold complex for the activation of alkynes and allenes towards nucleophilic addition has significantly enriched the toolkit of transformations available to the total synthesis community, and inspired a new era of creativity in terms of the strategic disconnection of target compounds during their retrosynthetic analysis. Instead of simply supplementing the many existing reviews of gold catalysis, this review has been organized from the perspective of synthetic target families, with particular emphasis on the use of gold-catalyzed transformations during the late stages of syntheses involving complicated substrates, and cascade reactions that significantly increase molecular complexity.

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Gold, foil, thickness 0.127 mm, 99.99% trace metals basis
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Gold, wire, diam. 0.25 mm, ≥99.9% trace metals basis
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Gold, nanopowder, <100 nm particle size, 99.9% trace metals basis
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Gold coated microscope slide, layer thickness 100 Å, 99.999% (Au)
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Gold, powder, <45 μm, 99.99% trace metals basis
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Gold, foil, thickness 0.5 mm, 99.99% trace metals basis
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Gold, wire, diam. 0.5 mm, 99.99% trace metals basis
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Gold, beads, 1-6 mm, 99.999% trace metals basis
Sigma-Aldrich
Gold coated microscope slide, layer thickness 1000 Å, 99.999% (Au)
Sigma-Aldrich
Gold, foil, thickness 0.025 mm, 99.99% trace metals basis
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Gold, wire, diam. 0.5 mm, 99.999% trace metals basis
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Gold, powder, <10 μm, ≥99.9% trace metals basis
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Gold, wire, diam. 0.1 mm, 99.99% trace metals basis
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Gold, foil, thickness 0.1 mm, 99.99% trace metals basis
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Gold, wire, diam. 1.0 mm, 99.99% trace metals basis
Gold, sphere, 50pcs, diameter 0.5mm, 99.99%
Sigma-Aldrich
Gold, foil, thickness 0.25 mm, ≥99.9% trace metals basis
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Gold, evaporation slug, diam. × L 0.3 cm × 0.6 cm, 99.99% trace metals basis
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Gold, wire, diam. 1.0 mm, 99.997% trace metals basis
Gold, sphere, 100pcs, diameter 0.5mm, 99.99%
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Gold, foil, thickness 0.05 mm, 99.99% trace metals basis
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Gold, powder, <850 μm, ≥99.99% trace metals basis
Gold, sphere, 200pcs, diameter 0.5mm, 99.99%
Sigma-Aldrich
Gold, wire, diam. 0.25 mm, 99.99% trace metals basis
Sigma-Aldrich
Gold, wire, diam. 0.127 mm, 99.99% trace metals basis
Gold, tube, 200mm, outside diameter 3.0mm, inside diameter 2.8mm, wall thickness 0.10mm, as drawn, 99.95%
Gold, insulated wire, 1m, conductor diameter 0.125mm, insulation thickness 0.014mm, polyester insulation, 99.99%
Gold, insulated wire, 0.1m, conductor diameter 0.10mm, insulation thickness 0.013mm, PTFE (polytetrafluoroethylene) insulation, 99.99%
Gold, insulated wire, 0.1m, conductor diameter 0.125mm, insulation thickness 0.016mm, PTFE (polytetrafluoroethylene) insulation, 99.99%
Gold, insulated wire, 0.2m, conductor diameter 0.025mm, insulation thickness 0.002mm, PTFE (polytetrafluoroethylene) insulation, 99.99%