Merck

Development of serum zinc as a biological dosimeter in mice.

International journal of radiation biology (2014-05-16)
Xuan-Yu Min, Xiao-Hong Zhang, Qi-Pu Zhou, Xiao-Dan Hu, Pei-Dang Liu, Hai-Qian Zhang
RESUMO

To develop a new biological dosimeter based on serum zinc concentration. Male mice (8 weeks old) were exposed to different doses (0, 1.0, 2.0, 4.0, or 8.0 Gy) of gamma rays from a (60)Co source. Blood was then collected from the orbital area of these mice, and the serum zinc concentration was detected using the 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol colorimetric method. The data were analyzed using one-way analysis of variance. The serum zinc concentration in the irradiated mice decreased with increasing dose. Two dose-response relationships fitted to the linear quadratic curve were obtained: One immediately after exposure (y = 0.010x(2) - 0.133x + 0.663, r = 0.983) and the other on the seventh day after exposure (y = 0.008x(2) - 0.127x + 0.695, r = 0.990). The serum zinc concentration continued to decrease until 21 days after exposure. The absorbed doses estimated using both dose-response relationships were close to the actual doses. Serum zinc is a quick, effective, and sensitive biomarker for early biological doses assessment of mice irradiated by gamma radiation.

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Zinc, foil, 15mm disks, thickness 1.0mm, as rolled, 99.95+%
Zinc, foil, 15mm disks, thickness 0.15mm, as rolled, 99.95+%
Zinc, foil, 0.3m coil, thickness 0.075mm, as rolled, 99.95+%
Zinc, foil, 10mm disks, thickness 0.5mm, as rolled, 99.99+%
Zinc, foil, 50x50mm, thickness 0.5mm, as rolled, 99.99+%
Zinc, foil, 15mm disks, thickness 0.05mm, as rolled, 99.95+%
Zinc, foil, 10mm disks, thickness 0.125mm, as rolled, 99.99+%
Zinc, foil, 0.5m coil, thickness 0.1mm, as rolled, 99.95+%
Zinc, foil, 10mm disks, thickness 0.25mm, as rolled, 99.95+%
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Zinc, foil, 50x50mm, thickness 0.35mm, as rolled, 99.95+%
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