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  • Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae.

Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae.

Aquatic toxicology (Amsterdam, Netherlands) (2014-12-03)
Biran Zhu, Qiangwei Wang, Xianfeng Wang, Bingsheng Zhou
RESUMO

Polybrominated diphenyl ethers (PBDEs) and metals are the main contaminants at waste electrical and electronic equipment ("e-waste") recycling sites. However, the potential environmental health effects of mixtures of PBDEs and metals are not known. We investigated co-exposure of lead (Pb) with decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae. Seven groups of embryos/larvae of zebrafish were treated with Pb (0, 2, 5, 10, 15, 20, and 30 μg/L), six groups were exposed to BDE-209 (0, 50, 100, 200, 400, and 800 μg/L), and nine groups of zebrafish larvae were treated with Pb and BDE-209 (5, 10, and 20 μg/L Pb; 50, 100, and 200 μg/L BDE-209). Embryos/larvae were exposed from 2h post-fertilization (hpf) until 144 hpf, and thyroid hormone (TH) content measured. Pb exposure significantly decreased whole-body TH contents (triiodothyroxine (T3) and thyroxine (T4)) but BDE-209 exposure significantly increased T3 and T4 levels. Pb or BDE-209 treatment alone caused a predicted downregulation of TH transport (i.e., expression of the mRNA or proteins of transthyretin). Chemical analyses showed Pb uptake to be increased by BDE-209, but BDE-209 bioconcentration was decreased and the ability to metabolize BDE-209 was reduced in the presence of Pb. We also found that a mixture of the two chemicals had a synergistic effect on TH levels in zebrafish.

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Sigma-Aldrich
Lead, powder, −100 mesh, 99.95% trace metals basis
Sigma-Aldrich
Lead, powder, −325 mesh, ≥99% trace metals basis
Sigma-Aldrich
Lead, wire, diam. 1.0 mm, 99.99% trace metals basis
Sigma-Aldrich
Lead, shot, 1-3 mm, 99.995% trace metals basis
Sigma-Aldrich
Lead, shot, <2 mm, 99.9% trace metals basis
Lead, foil, 150x150mm, thickness 0.5mm, as rolled, 99.95%
Lead, foil, 50x50mm, thickness 0.25mm, as rolled, 99.95%
Lead, foil, 50x50mm, thickness 0.1mm, as rolled, 99.95%
Lead, wire reel, 10m, diameter 0.25mm, as drawn, 99.95%
Lead, wire reel, 2m, diameter 0.125mm, as drawn, 99.5%
Lead, foil, 100x100mm, thickness 3.0mm, as rolled, 99.95%
Lead, foil, 100x100mm, thickness 3.0mm, as rolled, 99.99+%
Lead, foil, 100x100mm, thickness 6.0mm, as rolled, 99.99+%
Lead, foil, 150x150mm, thickness 0.125mm, as rolled, 99.95%
Lead, foil, 150x150mm, thickness 0.15mm, as rolled, 99.95%
Lead, foil, 150x150mm, thickness 0.1mm, as rolled, 99.95%
Lead, foil, 150x150mm, thickness 0.25mm, as rolled, 99.95%
Lead, foil, 150x150mm, thickness 0.55mm, as rolled, 99.999%
Lead, foil, 150x150mm, thickness 1.0mm, as rolled, 99.5%
Lead, foil, 150x150mm, thickness 1.0mm, as rolled, 99.95%
Lead, foil, 250x250mm, thickness 3.0mm, as rolled, 99.95%
Lead, foil, 25x25mm, thickness 0.125mm, as rolled, 99.95%
Lead, foil, 25x25mm, thickness 0.125mm, as rolled, 99.99+%
Lead, foil, 25x25mm, thickness 0.15mm, as rolled, 99.95%
Lead, foil, 25x25mm, thickness 0.1mm, as rolled, 99.95%
Lead, foil, 25x25mm, thickness 0.25mm, as rolled, 99.95%
Lead, foil, 25x25mm, thickness 0.25mm, as rolled, 99.99+%
Lead, foil, 25x25mm, thickness 0.55mm, as rolled, 99.999%
Lead, foil, 25x25mm, thickness 0.5mm, as rolled, 99.95%
Lead, foil, 25x25mm, thickness 0.5mm, as rolled, 99.99+%

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