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  • Chitosan conjugation: a facile approach to enhance the cell viability of LaF₃:Yb,Er upconverting nanotransducers in human breast cancer cells.

Chitosan conjugation: a facile approach to enhance the cell viability of LaF₃:Yb,Er upconverting nanotransducers in human breast cancer cells.

Carbohydrate polymers (2015-02-11)
Sethuraman Gayathri, Oriparambil Sivaraman Nirmal Ghosh, P Sudhakara, Annamraju Kasi Viswanath
ABSTRACT

In this study, chitosan functionalized LaF3:Yb,Er upconverting nanotransducers (UCNTs) with controlled size and shape have been successfully synthesized by a facile one pot precipitation method. The chitosan encapsulated UCNTs show bright upconversion fluorescence upon excitation with 974 nm NIR region. The average crystallite size of UCNTs about 7.6 nm was achieved using chitosan mediated synthesis. The FTIR result confirms the chitosan coating over the LaF3:Yb,Er nanoparticles. Due to the surface modification using natural biopolymer chitosan, the as-prepared nanocrystals show excellent biocompatibility even at high dose at 200 μg/ml. To the best of our knowledge the presented work is the first report on in vitro analysis of chitosan conjugated LaF3:Yb,Er upconverting nanocrystals in human breast (MCF-7) cancer cells. These nanotransducers can be used as luminescent probes for bioimaging and deep tissue cancer therapeutic applications.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Ammonium fluoride, ACS reagent, ≥98.0%
Sigma-Aldrich
Ammonium fluoride, puriss. p.a., ACS reagent, ≥98%
Ytterbium, lump, 25g, max. size 25mm, 99.9%
Ytterbium, foil, 25x25mm, thickness 0.125mm, as rolled, 99%
Ytterbium, foil, not light tested, 25x25mm, thickness 0.005mm, as rolled, 99%
Ytterbium, lump, 50g, max. size 25mm, 99.9%
Ytterbium, foil, 25x25mm, thickness 0.25mm, as rolled, 99%
Ytterbium, rod, 100mm, diameter 10.0mm, cast, 99%
Ytterbium, rod, 50mm, diameter 10.0mm, cast, 99%
Ytterbium, foil, 50x50mm, thickness 0.25mm, as rolled, 99%
Ytterbium, rod, 50mm, diameter 2.0mm, cast, 99%
Ytterbium, rod, 100mm, diameter 6.35mm, cast, 99%
Ytterbium, rod, 50mm, diameter 6.35mm, cast, 99%
Ytterbium, foil, not light tested, 25x25mm, thickness 0.025mm, as rolled, 99%
Ytterbium, foil, not light tested, 50x50mm, thickness 0.025mm, as rolled, 99%
Ytterbium, foil, 50x50mm, thickness 0.125mm, as rolled, 99%
Ytterbium, lump, 100g, max. size 25mm, 99.9%
Sigma-Aldrich
Ammonium fluoride, ≥99.99% trace metals basis
Sigma-Aldrich
Ytterbium, powder, ≥99.9% trace rare earth metals basis
Sigma-Aldrich
Ytterbium, ingot, 99.9% trace rare earth metals basis
Sigma-Aldrich
Ytterbium, chunks, 99.9% trace metals basis
Sigma-Aldrich
Ytterbium, chips, 99.9% trace rare earth metals basis
Sigma-Aldrich
Erbium, foil, thickness 1 mm, 99.9% trace rare earth metals basis
Sigma-Aldrich
Lanthanum(III) chloride hydrate, 99.9% trace metals basis
Sigma-Aldrich
Erbium, ingot, 99.9% trace rare earth metals basis
Sigma-Aldrich
Erbium, powder, −40 mesh, 99.9% trace rare earth metals basis
Sigma-Aldrich
Erbium, chips, 99.9% trace rare earth metals basis
Erbium, rod, 50mm, diameter 2.0mm, cast, 99%
Erbium, foil, not light tested, 25x25mm, thickness 0.005mm, as rolled, 99%
Erbium, foil, 50x50mm, thickness 0.125mm, as rolled, 99%