Dual Stimuli-Responsive Poly(β-amino ester) Nanoparticles for On-Demand Burst Release.

Macromolecular bioscience (2015-06-04)
Jung Seok Lee, Xiaojian Deng, Patrick Han, Jianjun Cheng

We designed poly(β-amino esters) (PBAEs) bearing both UV light- and pH-sensitive groups and used PBAEs to prepare nanoparticles (NPs) that can be utilized for on-demand burst release of guest molecules in response to multiple triggers. Due to the presence of the photo-cleavable group in each repeating unit of PBAE, rapid release of encapsulated model drug could be achieved even with exposures to low intensity UV (10 mW · cm(-2) ). Especially, the burst release was further accelerated by additional UV treatments in the acidic condition showing the combinatory effect of dual stimuli. We believe these PBAE-based NPs can potentially be used to design intelligent controlled release device and nanomedicines.

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Borane tetrahydrofuran complex solution, 1.0 M in THF
4-Amino-1-butanol, 98%