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  • Unusual compounds from Galium mollugo and their inhibitory activities against ROS generation in human fibroblasts.

Unusual compounds from Galium mollugo and their inhibitory activities against ROS generation in human fibroblasts.

Journal of pharmaceutical and biomedical analysis (2015-09-08)
Nassima Chaher, Stéphanie Krisa, Jean-Claude Delaunay, Stéphane Bernillon, Eric Pedrot, Jean-Michel Mérillon, Djebbar Atmani, Tristan Richard
RESUMO

Three unusual dioxatricyclodecenone compounds, mollugoside A, E-mollugoside B and Z-mollugoside B and, together with known flavonoids, were isolated from the aerial parts of Galium mollugo collected in north-eastern Algeria. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR. Flavonoids and mollugoside A significantly reduced reactive oxygen species (ROS) generation in human fibroblasts.

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