Merck

Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release.

Proceedings of the National Academy of Sciences of the United States of America (2017-03-08)
Chuchu Zhang, Katalin F Medzihradszky, Elda E Sánchez, Allan I Basbaum, David Julius
RESUMO

Pain-producing animal venoms contain evolutionarily honed toxins that can be exploited to study and manipulate somatosensory and nociceptive signaling pathways. From a functional screen, we have identified a secreted phospholipase A2 (sPLA2)-like protein, BomoTx, from the Brazilian lancehead pit viper (

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