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  • Brain uptake of deltamethrin in rats as a function of plasma protein binding and blood-brain barrier maturation.

Brain uptake of deltamethrin in rats as a function of plasma protein binding and blood-brain barrier maturation.

Neurotoxicology (2017-05-13)
Manoj Amaraneni, Jing Pang, Tanzir B Mortuza, Srinivasa Muralidhara, Brian S Cummings, Catherine A White, Charles V Vorhees, Jason Zastre, James V Bruckner
ABSTRACT

Pyrethroids, including permethrin and deltamethrin (DLM), are very widely used of insecticides. It was hypothesized that lower plasma binding and increased blood-brain barrier (BBB) penetration of DLM in immature rats contribute to the higher brain concentrations of DLM and more pronounced neurotoxicity reported in this age group. The left brain of anesthetized adult rats was perfused for 2min via a carotid artery with 1μM

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2,2,4-Trimethylpentane, ACS reagent, ≥99.0%