Transform Neuroscience Research

Ultrasensitive SMC® Neurology Immunoassays

High Sensitivity Immunoassays to Detect Neurology Biomarkers

Protein biomarkers have become a popular focus in recent decades for neurology research, particularly as targets for potential therapies for conditions such as Alzheimer’s disease, multiple sclerosis, and traumatic brain injury. Recent efforts in this field have begun incorporating the study of circulating samples for key biomarkers. This is because serum and plasma samples are much more easily accessible and versatile compared to cerebrospinal fluid (CSF), which is difficult to isolate from patients and typically available only in limited amounts. This shift in focus has required the development of assays with greater sensitivity than can be achieved from traditional immunoassay methods due to the lower expression of many key markers.

Harness the power of Single Molecule Counting (SMC®) high sensitivity immunoassay kits for accurate and reliable measurement of key neurology protein analytes from health through disease, using the powerful and intuitive SMCxPRO® immunoassay system.

Our growing menu of ultrasensitive assays for key neuro biomarkers includes:

  • Total Tau
  • Phospho-Tau (T181)
  • Amyloid Beta
  • Total Alpha Synuclein
  • Phospho-Alpha Synuclein (S129)
  • Brain-Derived Neurotrophic Factor (BDNF)
  • Glial Fibrillary Acidic Protein (GFAP)
  • Neurofilament Light Chain (NF-L) – coming soon!

COMING SOON: SMC® Neurofilament Light Chain (NF-L) High Sensitivity Immunoassay Kit

Few analytes symbolize the utility of ultrasensitive immunoassays in blood-based biomarker research better than Neurofilament Light Chain (NF-L), a product of axonal damage and a broadly applicable marker in brain biology. Ultrasensitive SMC® immunoassay technology on the SMCxPRO® platform enables researchers to study low-abundant blood-based neurodegenerative biomarkers like NF-L and profile subtle changes in expression.

Sign up for updates on our upcoming SMC® Human NF-L High Sensitivity Immunoassay Kit by filling out the form below and clicking the “Subscribe” checkbox. We are making final preparations to bring this powerful tool to your lab!

Development Data: Standard Curve Range and Serum NF-L Measurements

Data showing the measurement of Neurofilament Light Chain (NF-L) in plasma, serum, and CSF using the SMC<sup>&reg;</sup> NF-L High Sensitivity Immunoassay Kit.

Figure 1. The upcoming SMC® NF-L High Sensitivity Immunoassay Kit is designed to enable accurate measurement of NF-L in plasma and serum samples, in addition to cerebrospinal fluid.

Scatter plot showing data for concentration of Neurofilament Light Chain (NF-L) in healthy and Alzheimer’s Disease (AD) serum samples using the SMC® NF-L High Sensitivity Immunoassay Kit.

Figure 2. Scatter plot showing dilution-corrected interpolation of human healthy and Alzheimer’s Disease (AD) serum when tested using the upcoming SMC® NF-L High Sensitivity Immunoassay Kit. Horizontal bars indicate mean concentration values for each sample group.

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