MilliporeSigma
HomeIntegrated OfferingsmRNA Development & ManufacturingmRNA Research

mRNA Research

Synthetic mRNA is viewed as a viable and functional replacement for mature mRNA in both in vitro and in vivo research projects, including therapeutic development and delivery. Our comprehensive offering of premier tools and reagents helps you realize the potential of synthetic mRNA in your biopharmaceutical and life science research applications.

We provide a diverse portfolio of premium products to aid in your research, from tools and kits to isolate and purify total RNA to cells and enzymes that accelerate the synthesis of mRNA.


Related Technical Articles

  • Understand how mRNA vaccines induce immunity. and read how synthetic mRNA is prepared for vaccine immunogens and other biopharmaceuticals. Find reagents for synthesis of mRNA.
  • RT-qPCR products combine the effective of Reverse Transcriptase with hot-start taq-directed antibody in convenient ReadyMixes for probe-based or SYBR® Green based applications.

Related Protocols


Antigen Discovery Products

mRNA has demonstrated significant potential for the development of therapeutic approaches in infectious disease, genetic conditions, heart disease, oncology, and more. We support mRNA antigen discovery with:

mRNA Synthesis

For in vitro delivery of mRNA for applications such as stem cell induction, protein replacement, cancer immunotherapies, or vaccine modalities, synthetic mRNA has become a critical tool in diverse biopharmaceutical approaches. Our portfolio of mRNA synthesis products includes:

Lipid Nanoparticle (LNP) Selection and Formulation

Lipid nanoparticles (LNPs) are critical vehicles for mRNA delivery - encapsulating and conveying mRNA safely to cells. LNP selection is integral at the earliest stages of vaccine and therapeutic mRNA delivery research. We offer a comprehensive portfolio for lipid selection and LNP formulation, including:

  • Non-GMP lipids for use in mRNA targeting and delivery research, such as cationic lipids, PEG and structural lipids, and cholesterol
  • NanoFabTx™ reagent and microfluidic device kits provide a ready-to-use platform to screen multiple formulations, and ultimately synthesize mRNA or drug-encapsulated liposomes for preclinical assessments.

Our Products and Services Support the Following Areas

Research

Test
• Antigen Discovery Products
• mRNA Synthesis
• LNP Selection and Formulation

    Development

    mRNA-development
    • Characterization and Method Development
    • Plasmid DNA Production and mRNA Synthesis & Purification
    • mRNA Contract Development and Manufacturing Services
    • Lipid Nanoparticle Formulation (LNP)
    • Preclinical Assessment
    • mRNA Development Services

      Manufacturing & Formulation

      mRNA-manufacturing-and-formulation
      • mRNA Synthesis and Purification Products
      • mRNA Contract Development and Manufacturing Services
      • Lipid Nanoparticle Formulation (LNP)
      • Cell Banking and Storage
      • Facility Engineering Services
      • mRNA Testing Services

        Analytical & Quality Control

        mRNA-analytics-and-quality-control
        • Analytical Quality Control
        • Microbial Quality Control