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719897

Sigma-Aldrich

Resomer® RG 502 H, Poly(D,L-lactide-co-glycolide)

acid terminated, viscosity 0.16-0.24 dL/g 

Resomer® RG 502 H, Poly(D,L-lactide-co-glycolide)
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Synonym(s):

PLGA

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About This Item

Linear Formula:
[C3H4O2]x[C2H2O2]y
CAS Number:
26780-50-7
MDL number:
MFCD00131930
UNSPSC Code:
12162002
NACRES:
NA.23

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Quality Level

200

form

amorphous

feed ratio

lactide:glycolide 50:50

degradation timeframe

<3 months

viscosity

0.16-0.24 dL/g

transition temp

Tg 42-46 °C

storage temp.

2-8°C

SMILES string

O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

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1 of 4

This Item
739952719927739979
Resomer&#174; RG 502 H, Poly(D,L-lactide-co-glycolide) acid terminated, viscosity 0.16-0.24&#160;dL/g&#160;

Sigma-Aldrich

719897

Resomer® RG 502 H, Poly(D,L-lactide-co-glycolide)

Resomer&#174; RG 503, Poly(D,L-lactide-co-glycolide) lactide:glycolide 50:50, ester terminated, Mw 24,000-38,000

Sigma-Aldrich

739952

Resomer® RG 503, Poly(D,L-lactide-co-glycolide)

Resomer&#174; RG 756 S, Poly(D,L-lactide-co-glycolide) ester terminated, lactide:glycolide 75:25, Mw 76,000-115,000

Sigma-Aldrich

719927

Resomer® RG 756 S, Poly(D,L-lactide-co-glycolide)

Resomer&#174; RG 858 S, Poly(D,L-lactide-co-glycolide) ester terminated, lactide:glycolide 85:15, Mw 190,000-240,000

Sigma-Aldrich

739979

Resomer® RG 858 S, Poly(D,L-lactide-co-glycolide)

viscosity

0.16-0.24 dL/g

viscosity

0.32-0.44 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

viscosity

0.71-1.0 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

viscosity

1.3-1.7 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

form

amorphous

form

amorphous

form

amorphous

form

amorphous

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

feed ratio

lactide:glycolide 50:50

feed ratio

lactide:glycolide 50:50

feed ratio

lactide:glycolide 75:25

feed ratio

lactide:glycolide 85:15

degradation timeframe

<3 months

degradation timeframe

<3 months

degradation timeframe

<6 months

degradation timeframe

<9 months

transition temp

Tg 42-46 °C

transition temp

Tg 44-48 °C

transition temp

Tg 49-55 °C

transition temp

-

Application

Poly(D,L-lactide-co-glycolide) (PLGA) canbe used:

  • In the formulation ofa non-aqueous drug delivery system for H2S donors to aid thesustained release of the drug.
  • To prepare a polymer blend containing Ganciclovir-loaded microspheresdispersed in PLGA–PEG–PLGA polymer gel. This formulation can be used as asustained delivery system for Ganciclovir drug.
It can also be used to fabricate NO-releasingglucose and lactate sensors.

Legal Information

Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX7331
MKCX2944
MKCX2102
MKCV8978
BCCH1660

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Qinyi Yan et al.
Biosensors & bioelectronics, 26(11), 4276-4282 (2011-05-20)
Intravenous amperometric needle-type enzymatic glucose/lactate sensors intended for continuous monitoring are prepared with a novel nitric oxide (NO) releasing layer to improve device hemocompatibility. To create an underlying NO release coating, the sensors with immobilized enzymes (either glucose oxidase or
A Patil et al.
AAPS PharmSciTech, 18(6), 2291-2302 (2017-01-20)
Hydrogen sulfide (H2S) targets both underlying factors in glaucoma pathogenesis by reducing elevated intraocular pressure (IOP) and providing retinal neuroprotection, whereas the current clinical approaches targets only reducing IOP. Therefore, H2S could be a potential superior candidate for glaucoma pharmacotherapy.
Diazeniumdiolate-doped poly (lactic-co-glycolic acid)-based nitric oxide releasing films as antibiofilm coatings.
Cai W,et al.
Biomaterials, 33(32), 7933-7944 (2012)
Sridhar Duvvuri et al.
Journal of controlled release : official journal of the Controlled Release Society, 108(2-3), 282-293 (2005-10-19)
The purpose of this work is to develop empirical equations for describing the in vitro ganciclovir (GCV) release from PLGA microspheres and also to develop and characterize a formulation containing GCV loaded PLGA microspheres dispersed in thermogelling PLGA-PEG-PLGA polymer gel.
Z Zhuang et al.
Journal of dental research, 98(2), 200-208 (2018-11-06)
Periodontitis is characterized by the progressive destruction of tooth-supporting alveolar bone, which is mainly caused by chronic inflammation in response to persistent bacterial insult. It has recently become clear that the pathogenesis of periodontitis is associated with a high ratio
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Questions

1–5 of 5 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. Is this material a Pharmaceutical Secondary Standard (Certified Reference Material)?

    1 answer

    1. This product is not a pharmaceutical secondary standard.

      Helpful?

  3. Resomer® RG 502 H, Catalogue No.719897 Q1: Why the Molecular weight of this product is in a range from 7000-17000 and not fixed? Q2: How many COOH groups will be there for each molecule? Q3: Is PLGA made in random or alternative block design?

    1 answer

    1. Q1: The molecular weight range of 7000-17000 is a specification range, and the exact molecular weight is determined on a lot-to-lot basis, as listed on the Certificate of Analysis.

      Q2: The number of COOH groups per molecule is not tested. The acid value, which can be referenced, has a specification range of ≥ 6.0 mg KOH/g.

      Q3: This product is Poly(D,L-lactide-co-glycolide), where "-co-" indicates an unspecified arrangement. Information on block design is not available, and there is no Poly(D,L-lactide-ran-glycolide) or Poly(D,L-lactide-alt-glycolide) available.

      Helpful?

  4. Qual è il range di pesp molecolare di questo polimero?

    1 answer

    1. The Resomer RG group of products has a molecular weight range of 7000 - 240,000 daltons. The value is lot specific and reported in the product Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
      https://www.sigmaaldrich.com/product/aldrich/719897#product-documentation

      Helpful?

  5. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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