KITALYSIS-CN

KitAlysis^™ High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4

• Synonym(s): Amination Screening Kit, Buchwald-Hartwig Amination
• NACRES: NA.22
• UNSPSC Code: 12161503

Properties

• product line: KitAlysis^™
• reaction suitability: reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Cross Couplings, reagent type: catalyst; core: palladium
• storage temp.: room temp

Description

General description

The KitAlysis^™ High Throughput Buchwald–Hartwig Amination Reaction Screening Kit enables chemists to quickly and efficiently screen Buchwald–Hartwig C–N cross-coupling reaction conditions. Quick identification of optimal conditions allows faster scale-up of the synthetic reaction. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.

Application

There are four possible screens that can be run based upon the user’s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.

Two Solvents, Weak Base (Cs₂CO₃)
Download the experimental excel file here
Two Solvents, Strong Base (NaOt-Bu)
Download the experimental excel file here
One Solvent (Dioxane), Two Bases
Download the experimental excel file here
One Solvent (DMAc), Two Bases
Download the experimental excel file here

Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains

• 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars
• 2 bases (NaOt-Bu and Cs₂CO₃)
• 2 degassed anhydrous solvents (dioxane and DMAc) in ampules
• 2 substrate reaction vials with stir bars
• 1 internal standard
• 4 reaction block replacement films

Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

• Designed and tested by synthetic chemists
• Easily run 24-microscale reaction in parallel
• 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration
• Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Kit Components Only

• SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

Kit Components Also Available Separately

• 900634

  N,N-Dimethylacetamide, anhydrous, ZerO₂^®, 99.8% 8 mL

  SDS
• 900640

  1,4-Dioxane, anhydrous, ZerO₂^®, 99.8% 8 mL

  SDS
• 702706

  Sodium tert-butoxide solution, 2 M in THF, ZerO₂^® 4 mL

  SDS
• 747130

  Josiphos SL-J009-1 Pd G3 5 µmol

  SDS
• 753009

  SPhos Pd G2 5 µmol

  SDS
• 753246

  RuPhos Pd G2 5 µmol

  SDS
• 756482

  P(t-Bu)₃ Pd G2 5 µmol

  SDS

See All (15)

Safety Information

• pictograms: GHS02,GHS08,GHS05,GHS07,GHS09
• signalword: Danger
• hcodes: H251,H312 + H332,H314,H335,H336,H350,H360Df,H373,H410
• pcodes: P235 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Dam. 1 - Repr. 1B - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 Oral - STOT SE 3
• target_organs: Central nervous system, Kidney,Adrenal gland,Testes, Respiratory system
• Storage Class: 4.2 - Pyrophoric and self-heating hazardous materials
• flash_point_f: -4.0 °F - closed cup
• flash_point_c: -20 °C - closed cup
• wgk: WGK 3
• supp_hazards: EUH014,EUH019