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118415

ADP-HPD, Dihydrate, Ammonium Salt

≥95% (HPLC), lyophilized solid, PARG inhibitor, Calbiochem®

Synonym(s):

ADP-HPD, Dihydrate, Ammonium Salt, Adenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH4

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Size/SKUAvailabilityPrice
60 μg
Please contact Customer Service for Availability
$319.00
1 set
Please contact Customer Service for Availability
$1,190.00

About This Item

Empirical Formula (Hill Notation):
C15H23N6O12P2 · NH4 · 2H2O
Molecular Weight:
595.39
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

$319.00

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Product Name

ADP-HPD, Dihydrate, Ammonium Salt, ADP-HPD, Dihydrate is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).

Quality Segment

100

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

water: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC50 = 260 µM). Note: 1 set = 5 x 60 µg.
Note: 1 set = 5 x 60 µg

Biochem/physiol Actions

Cell permeable: no
Primary Target
PARG
Product does not compete with ATP.
Reversible: no
Target IC50: 120 nM against poly(ADP-ribose) glycohydrolase (PARG)

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.

Other Notes

Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 9886.
Slama, J.T., et al. 1995. J. Med. Chem.38, 389.
Slama, J.T., et al. 1995. J. Med. Chem.38, 4332.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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ADP-HPD, Dihydrate, Ammonium Salt ADP-HPD, Dihydrate is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).

Sigma-Aldrich

118415

ADP-HPD, Dihydrate, Ammonium Salt

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Sigma-Aldrich

116812

Adenosine 3′,5′-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt

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Sigma-Aldrich

116814

Adenosine 3′,5′-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt

Okadaic Acid, Ammonium Salt Water-soluble analog of Okadaic Acid. Inhibits protein phosphatases 1 and 2A.

Sigma-Aldrich

459616

Okadaic Acid, Ammonium Salt

form

lyophilized solid

form

solid

form

crystalline solid

form

solid

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (TLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

water: 5 mg/mL

solubility

water: 10 mg/mL

solubility

water: 20 mg/mL

solubility

water: 1 mg/mL, DMSO: 20 mg/mL, ethanol: 20 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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