MilliporeSigma

137151

SAFC

2-Mercaptoethanol

EMPROVE® EVOLVE

Synonym(s):
β-Mercaptoethanol, 2-Hydroxyethylmercaptan, BME, Thioethylene glycol
Linear Formula:
HSCH2CH2OH
CAS Number:
Molecular Weight:
78.13
Beilstein:
773648
MDL number:

vapor density

2.69 (vs air)

Quality Level

vapor pressure

1 mmHg ( 20 °C)

form

liquid

expl. lim.

18 %

concentration

14.3 M (pure liquid)
99.0-101.0 % (w/w)

impurities

≤1.0% related substances (GC) 2,2-Dithiodiethanol

refractive index

n20/D 1.500 (lit.)

bp

157 °C (lit.)

density

1.114 g/mL at 25 °C (lit.)

suitability

corresponds for identity (IR)

application(s)

pharma/biopharma processes

storage temp.

2-8°C

SMILES string

OCCS

InChI

1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2

InChI key

DGVVWUTYPXICAM-UHFFFAOYSA-N

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This Item
M62506368997622
2-Mercaptoethanol EMPROVE® EVOLVE

SAFC

137151

2-Mercaptoethanol

2-Mercaptoethanol ≥99.0%

Sigma-Aldrich

M6250

2-Mercaptoethanol

2-Mercaptoethanol BioUltra, for molecular biology, ≥99.0% (GC)

Sigma-Aldrich

63689

2-Mercaptoethanol

2-Mercaptoethanol for HPLC derivatization, LiChropur™, ≥99.0% (GC)

Supelco

97622

2-Mercaptoethanol

vapor pressure

1 mmHg ( 20 °C)

vapor pressure

1 mmHg ( 20 °C)

vapor pressure

1 mmHg ( 20 °C)

vapor pressure

1 mmHg ( 20 °C)

form

liquid

form

liquid

form

liquid

form

liquid

expl. lim.

18 %

expl. lim.

18 %

expl. lim.

18 %

expl. lim.

18 %

concentration

14.3 M (pure liquid)

concentration

14.3 M (pure liquid)

concentration

14.3 M (pure liquid)

concentration

14.3 M (pure liquid)

impurities

≤1.0% related substances (GC) 2,2-Dithiodiethanol

impurities

-

impurities

DNases, none detected, RNases, none detected, insoluble matter, passes filter test, phosphatases, none detected, proteases, none detected

impurities

-

General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

As part of our EMPROVE® Program, our raw materials are offered with EMPROVE® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Application

BME is suitable for reducing protein disulfide bonds prior to polyacrylamide gel electrophoresis and is usually included in a sample buffer for SDS-PAGE at a concentration of 5%. Cleaving intermolecular (between subunits) disulfide bonds allows the subunits of a protein to separate independently on SDS-PAGE. Cleaving intramolecular (within subunit) disulfide bonds allows the subunits to become completely denatured so that each peptide migrates according to its chain length with no influence due to secondary structure.

Analysis Note

purity (GC) ≥99.0%

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(C)

74 °C - closed cup


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