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189400

Sigma-Aldrich

Aurintricarboxylic Acid

A cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes.

Synonym(s):

Aurintricarboxylic Acid, ATA

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100 MG
$72.70

About This Item

Empirical Formula (Hill Notation):
C22H14O9
CAS Number:
Molecular Weight:
422.34
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.77

$72.70


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Quality Level

description

RTECS - GU4790000

Assay

≥85% (titration)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

red

solubility

0.1 M NaOH: 35 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C22H16O9.3H3N/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31;;;/h1-10,19,24-25H,(H,26,27)(H,28,29)(H,30,31);3*1H3

InChI key

UDPQMNAHKKTHHI-UHFFFAOYSA-N

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This Item
104550A1895475913
ACA A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets.

104550

ACA

assay

≥85% (titration)

assay

≥99% (HPLC)

assay

≥85% (titration)

assay

≥95% (HPLC)

form

solid

form

solid

form

powder

form

solid

Quality Level

100

Quality Level

100

Quality Level

300

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

storage temp.

10-30°C

storage temp.

10-30°C

storage temp.

room temp

storage temp.

10-30°C

solubility

0.1 M NaOH: 35 mg/mL

solubility

ethanol: 10 mg/mL, DMSO: 50 mg/mL

solubility

1 M NH4OH: 10 mg/mL

solubility

0.1 M NaOH: 10 mg/mL, ethanol: soluble

General description

A cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Binds to aFGF and reduces its angiogenic activity. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is a potent inhibitor of DNA topoisomerase II (IC50= 75 nM for the yeast enzyme as measured by relaxation assays) that also acts as a potent inhibitor of angiogenesis. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA stimulates the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase Cγ. Inhibits both major calpain isoforms (IC50 = 22 µM and IC50 = 10 µM for µ-calpain and m-calpain, respectively).
Dye content: ~85%.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
DNA topoisomerase 2
Product does not compete with ATP.
Reversible: no
Target IC50: 75 nM against DNA topoisomerase II

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Lozano, R.M., et al. 1997. Eur. J. Biochem.248, 30.
Benchokroun, Y., et al. 1995. Biochem. Pharmacol.49, 305.
Okada, N., and Koizumi, S. 1995. J. Biol. Chem.270, 16464.
Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291.
Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853.
Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101.
Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475.
Gonzalez, R.G., et al. 1980. Biochemistry19, 4299.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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