205531

CA-074 Me

≥98% (HPLC), solid, Cathepsin B inhibitor, Calbiochem^®

• Synonym(s): CA-074 Me, Cathepsin B Inhibitor IV, [L-3- trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
• Empirical Formula (Hill Notation): C₁₉H₃₁N₃O₆
• Molecular Weight: 397.47
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Product Name: CA-074 Me, CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cathepsin B

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2.24 nM against cathepsin B

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sever, N., et al. 2002. Biol. Chem.383, 839.
Authier, F., et al. 1999. J. Biol. Chem.274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable