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217696

Sigma-Aldrich

Cdk1 Inhibitor

CGP74514A

Synonym(s):

Cdk1 Inhibitor

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5 MG
$394.00

$394.00

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5 MG
$394.00

About This Item

CAS Number:
190654-01-4
UNSPSC Code:
12352200
NACRES:
NA.77

$394.00

Please contact Customer Service for Availability
Request a Bulk Order

form

(Off-white solid)

solubility

soluble (DMSO (10 mg/ml))

storage temp.

−20°C

General description

A cell-permeable, potent, reversible, ATP-competitive and selective inhibitor of Cdk1/cyclin B (IC50 = 25 nM). Affects the activities of other kinases only at higher concentrations (IC50 = 6.1 µM for PKCα, 125 µM for PKA, and >10 µM for EGFR). Also reported to induce mitochondrial damage and apoptosis in several human leukemia cell lines (>3 µM). At lower concentrations (~1 µM) an initial G2M cell cycle arrest and eventual apoptosis has been reported to occur in U937 cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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