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233156

Millipore

Cleland′s Reagent, Molecular Biology Grade

A protective agent for SH groups.

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Synonym(s):
Cleland’s Reagent, Molecular Biology Grade, 1,4-Dithiothreitol, DTT
Empirical Formula (Hill Notation):
C4H10O2S2
CAS Number:
Molecular Weight:
154.25
MDL number:

grade

Molecular Biology

Quality Level

Assay

≥99% (titration)

form

powder
solid

reaction suitability

reagent type: reductant

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

water: 15 mg/mL

cation traces

heavy metals: ≤0.001%

absorption

≤0.100 at 280 nm at 100 mM (1 cm)
≤0.500 at 260 nm at 100 mM (1 cm)

foreign activity

DNases, proteases, RNases, none detected

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m0/s1

InChI key

VHJLVAABSRFDPM-IMJSIDKUSA-N

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This Item
D9779233153-M646563
DL-Dithiothreitol for molecular biology, ≥98% (HPLC), ≥99% (titration)

Sigma-Aldrich

D9779

DL-Dithiothreitol

Cleland′s Reagent ULTROL® Grade, ≥99% (titration), protective agent for SH groups

Millipore

233153-M

Cleland′s Reagent

DL-Dithiothreitol solution 1 M in H2O

Supelco

646563

DL-Dithiothreitol solution

form

powder, solid

form

powder

form

solid

form

liquid

reaction suitability

reagent type: reductant

reaction suitability

reagent type: reductant

reaction suitability

reagent type: reductant

reaction suitability

reagent type: reductant

solubility

water: 15 mg/mL

solubility

H2O: 50 mg/mL

solubility

water: 200 mM, ethanol: soluble

solubility

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

General description

A protective agent for SH groups.
Water-soluble protective reagent for sulfhydryl groups [absorbance (100 mM): ≤0.5 at 260 nm; ≤0.1 at 280 nm]. It is capable of maintaining monothiols completely in the reduced state and of reducing disulfides quantitatively. Since it readily permeates cell membranes, it can protect protein sulfhydryls and restore enzyme activity lost by oxidation.

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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