234491
PD 153035
InSolution, ≥97%, potent and specific inhibitor of the tyrosine kinase activity of EGFR
Synonym(s):
InSolution PD 153035
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About This Item
Empirical Formula (Hill Notation):
C16H14BrN3O2
Molecular Weight:
360.21
UNSPSC Code:
12352200
Quality Level
Assay
≥97% (HPLC)
form
liquid
potency
25 pM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in
wet ice
storage temp.
2-8°C
General description
An extremely potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target Ki: 6 pM against the tyrosine kinase activity of the epidermal growth factor receptor (EGFR)
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Physical form
A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234490) in DMSO.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Flash Point(C)
87 °C - closed cup - (Dimethylsulfoxide)
Certificates of Analysis (COA)
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DNA methylation and expression of the egfr gene are associated with worker size in monomorphic ants.
Thibaut Renard et al.
Scientific reports, 12(1), 21228-21228 (2022-12-10)
The reproductive division of labour is a hallmark of eusocial Hymenoptera. Females are either reproductive queens or non-reproductive workers. In ants, workers often display further task specialisation that is associated with variation in size and/or morphology. Because female polyphenism is
Carolina Franco Nitta et al.
eLife, 10 (2021-11-26)
Crosstalk between different receptor tyrosine kinases (RTKs) is thought to drive oncogenic signaling and allow therapeutic escape. EGFR and RON are two such RTKs from different subfamilies, which engage in crosstalk through unknown mechanisms. We combined high-resolution imaging with biochemical
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