Dkk-1 Inhibitor, WAY-262611, HCl

Name: Dkk-1 Inhibitor, WAY-262611, HCl
Brand: MM
Price: 259 CAD

The Dkk-1 Inhibitor, WAY-262611 controls the biological activity of Dkk-1.

Synonym(s):

Dkk-1 Inhibitor, WAY-262611, HCl, (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI

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10 MG

$259.00

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₂N₄ · xHCl

Molecular Weight:

318.42 (free base basis)

UNSPSC Code:

12352200

NACRES:

NA.77

Key Documents

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Quality Level

100

Assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

Related Categories

Bioactive Small Molecule Inhibitors

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This Item	317701	681667	681674
Sigma-Aldrich 317700 Dkk-1 Inhibitor, WAY-262611, HCl	Sigma-Aldrich 317701 Dkk Inhibitor II, IIIC3a	Sigma-Aldrich 681667 Wnt Agonist II, SKL2001	Sigma-Aldrich 681674 Wnt Pathway Inhibitor XI, CCT036477
assay ≥95% (HPLC)	assay ≥90% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (¹H-NMR)
form powder	form powder	form solid	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition OK to freeze, protect from light	storage condition OK to freeze, desiccated (hygroscopic), protect from light	storage condition OK to freeze, protect from light	storage condition OK to freeze, protect from light

General description

A 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC₅₀ = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.

Packaging

Packaged under inert gas

Other Notes

Pelletier, J.C., et al. 2009. J. Med. Chem.52, 6962.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization.

Yifan Wu et al.

Immunity, 54(11), 2595-2610 (2021-09-11)

Fungal airway infection (airway mycosis) is an important cause of allergic airway diseases such as asthma, but the mechanisms by which fungi trigger asthmatic reactions are poorly understood. Here, we leverage wild-type and mutant Candida albicans to determine how this

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Dkk-1 Inhibitor, WAY-262611, HCl