420118

JNK Inhibitor I, (L)-Form, Cell-Permeable, Negative Control

The JNK Inhibitor I, (L)-Form, Cell-Permeable, Negative Control controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): JNK Inhibitor I, (L)-Form, Cell-Permeable, Negative Control, (L)-HIV-TAT₄₈₋₅₇-PP, GRKKRRQRRRPP-NH₂
• Empirical Formula (Hill Notation): C₆₅H₁₂₄N₃₄O₁₃
• Molecular Weight: 1589.90
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• solubility: water: 2 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A highly cell-permeable 10-amino acid carrier peptide derived from HIV-TAT_48-57 sequence that is modified with two proline residues. Shown to accumulate into a variety of cells. Serves as a useful negative control for studies involving JNK Inhibitor I, (L)-Form, Cell-Permeable (Cat. No. 420116).

A highly cell-permeable carrier decapeptide derived from HIV-TAT_48-57 sequence that is modified with two proline residues. Serves as a useful negative control for studies involving JNK Inhibitor I, (L)-Form, Cell-permeable (Cat. No. 420116).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
A useful negative control for studies involving JNK Inhibitor I, (L)-Form, Cell-Permeable

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Bonny, C., et al. 2001. Diabetes50, 77.
Vocero-Akbani, A. M., et al 1999. Nat. Med.5, 29.
Schwarze, S. R., et al. 1999. Science285, 1573.
Nagahara, H., et al. 1998. Nat. Med.4, 1449.
Vives, E., et al. 1997. J. Biol. Chem.272, 16010.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable