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454585

Sigma-Aldrich

NMDA Receptor NR2BCT(1292-1304)-TAT

A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of NMDAR function

Synonym(s):

NMDA Receptor NR2BCT(1292-1304)-TAT, H-KKNRNKLRRQHSY-Ahx-YGRKKRRQRRR-NH₂, Tat-NR2B CT

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About This Item

Empirical Formula (Hill Notation):
C143H254N64O32
Molecular Weight:
3381.96
UNSPSC Code:
12352200

Quality Level

Assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 (death-associated protein kinase 1) in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of NMDAR function with no effect on either the catalytic activity of DAPK1 or the NMDA receptor physiology. Blocks Ca2+ influx through extrasynaptic NMDA receptors (at 50 µM) and the blood-brain-barrier permeable version, namely NR2BCT(1292-1304) attached to TAT(47-57) via a spacer (6-aminohexanoic acid) protects cortical neurons from NMDA receptor-mediated insults and reduces brain infarction and improve neurological functions in mice (10 mg/kg, i.v.).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

H₂N-Lys-Lys-Asn-Arg-Asn-Lys-Leu-Arg-Arg-Gln-His-Ser-Tyr-Ahx-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-CONH₂

Physical form

Supplied as a trifluoroacetate salt

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Tu, W., et al. Cell140, 222.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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