506157

p38 MAP Kinase Inhibitor VI, JX401

The p38 MAP Kinase Inhibitor VI, JX401, also referenced under CAS 349087-34-9, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): p38 MAP Kinase Inhibitor VI, JX401, N-(2-Methoxy-4-thiomethyl)benzoyl-4-benzylpiperidine
• Empirical Formula (Hill Notation): C₂₁H₂₅NO₂S
• CAS Number: 349087-34-9
• Molecular Weight: 355.49
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: ethanol: 17 mg/mL; DMSO: 26 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3
• InChI key: OMGLGPKQUFSRNN-UHFFFAOYSA-N

Description

General description

A cell-permeable piperidinamide compound that acts as a reversible and highly potent inhibitor of MAPK p38α (IC₅₀ = 32 nM) with no detectable activity against p38γ even at concentrations as high as 10 µM. Shown to effectively block the differentiation of L8 myoblasts to myotubes at 10 µM in a reversible manner. Not a competitive inhibitor with respect to either ATP or substrate.

Packaging

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Friedmann, Y., et al. 2006. Mol. Pharmacol.70, 1395.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable