The stability of this inhibitor in cell culture media has not been evaluated in-house and is expected to vary from one cell culture model system to another. The required frequency of refreshing culture medium containing this inhibitor should be determined empirically for the specific model system. Published literature may be used as a guide.
551476
Q-VD-OPh, Non-O-methylated
≥90% (HPLC), liquid, Caspase inhibitor, Calbiochem®
Synonym(s):
InSolution Q-VD-OPh, Non-O-methylated, N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
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1 MG
$358.00
5 MG
$1,180.00
$358.00
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1 MG
$358.00
5 MG
$1,180.00
About This Item
Empirical Formula (Hill Notation):
C26H25F2N3O6
Molecular Weight:
513.49
UNSPSC Code:
12352200
NACRES:
NA.77
$358.00
Please contact Customer Service for Availability
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Product Name
Q-VD-OPh, Non-O-methylated, InSolution, ≥90%, irreversible broad-spectrum inhibitor of caspases
Quality Level
Assay
≥90% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in
wet ice
storage temp.
−20°C
General description
A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-1
caspase-1
Product does not compete with ATP.
Reversible: no
Target IC50: 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Sequence
Q-Val-Asp-CH₂-OPh
Physical form
Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Braun, J.S., et al. 2007. Exp. Neurol.206, 183.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Flash Point(C)
87 °C - closed cup - (Dimethylsulfoxide)
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Sara H Small et al.
Science signaling, 14(714), eaba2611-eaba2611 (2021-12-22)
Cytokine production is a critical component of cell-extrinsic responses to DNA damage and cellular senescence. Here, we demonstrated that expression of the gene encoding interleukin-19 (IL-19) was enhanced by DNA damage through pathways mediated by c-Jun amino-terminal kinase (JNK) and
Joshua D Bryant et al.
Current protocols, 2(2), e372-e372 (2022-02-18)
Mitochondria have emerged as key drivers of mammalian innate immune responses, functioning as signaling hubs to trigger inflammation and orchestrating metabolic switches required for phagocyte activation. Mitochondria also contain damage-associated molecular patterns (DAMPs), molecules that share similarity with pathogen-associated molecular
Javier Chicote et al.
Frontiers in pharmacology, 11, 580343-580343 (2020-11-13)
Macroautophagy (hereafter autophagy) is a multistep intracellular catabolic process with pleiotropic implications in cell fate. Attending to its activation, autophagy can be classified into inducible or constitutive. Constitutive, or basal autophagy, unfolds under nutrient-replete conditions to maintain the cellular homeostasis.
Yuanjiu Lei et al.
Cell, 186(14), 3013-3032 (2023-06-24)
Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic acid sensors remain poorly defined. Here, we show that mitochondrial genome instability promotes
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Is Q-VD-OPh, Non-O-methylated and Bcl-2 Inhibitor VI, ABT-737 – CAS 852808-04-9-Calbiochem (197333, reconstituted in DMSO) stable in cell culture media at 37C for cell-based assays?
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