The stability of this inhibitor in cell culture media has not been evaluated in-house and is expected to vary from one cell culture model system to another. The required frequency of refreshing culture medium containing this inhibitor should be determined empirically for the specific model system. Published literature may be used as a guide.
551476
Q-VD-OPh, Non-O-methylated
≥90% (HPLC), liquid, Caspase inhibitor, Calbiochem®
Synonym(s):
InSolution Q-VD-OPh, Non-O-methylated, N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
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1 MG
$358.00
5 MG
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About This Item
Empirical Formula (Hill Notation):
C26H25F2N3O6
Molecular Weight:
513.49
UNSPSC Code:
12352200
NACRES:
NA.77
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$358.00
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Product Name
Q-VD-OPh, Non-O-methylated, InSolution, ≥90%, irreversible broad-spectrum inhibitor of caspases
Quality Level
Assay
≥90% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in
wet ice
storage temp.
−20°C
1 of 4
This Item | 235427 | 217721 | 496000 |
|---|---|---|---|
| assay ≥90% (HPLC) | assay ≥90% (HPLC) | assay ≥95% (HPLC) | assay ≥90% (HPLC) |
| form liquid | form liquid | form liquid | form liquid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| storage temp. −20°C | storage temp. −20°C | storage temp. −70°C | storage temp. −20°C |
| storage condition OK to freeze, protect from light, desiccated (hygroscopic) | storage condition OK to freeze, desiccated (hygroscopic), protect from light | storage condition OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light | storage condition OK to freeze, desiccated, protect from light |
General description
A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-1
caspase-1
Product does not compete with ATP.
Reversible: no
Target IC50: 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Sequence
Q-Val-Asp-CH₂-OPh
Physical form
Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Braun, J.S., et al. 2007. Exp. Neurol.206, 183.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Flash Point(C)
87 °C - closed cup - (Dimethylsulfoxide)
Certificates of Analysis (COA)
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