553003

Raf1 Kinase Inhibitor I

InSolution, ≥97%

• Synonym(s): InSolution Raf1 Kinase Inhibitor I
• Empirical Formula (Hill Notation): C₁₅H₈Br₂INO₂
• Molecular Weight: 520.94
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: clear orange
• shipped in: wet ice
• storage temp.: 2-8°C

Description

General description

A potent cRaf1 kinase inhibitor (IC₅₀ = 9 nM). Shows ~100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms. cRaf1 inhibitors are predicted to be broad spectrum anti-tumor agents.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
CRAFI kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 9 nM against cRAF1 kinase

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

A 10 mM (500 µg/96 µl) solution of Raf1 Inhibitor I (Cat. No. 553008) in DMSO.

Reconstitution

Following initial use, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Flash Point(C): 87 °C - closed cup - (Dimethylsulfoxide)