559408
SB 220025, Trihydrochloride
Synonym(s):
5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
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500 μG
$190.00
$190.00
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500 μG
$190.00
About This Item
UNSPSC Code:
41106305
$190.00
Please contact Customer Service for Availability
form
white solid
Quality Level
storage condition
OK to freeze
solubility
soluble (H2O (22 mg/ml))
storage temp.
−20°C
General description
A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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