682162

Xestospongin D, Xestospongia sp.

A reversible, membrane-permeable blocker of IP3-mediated Ca²⁺ release (IC₅₀ = 648 nM).

• Synonym(s): Xestospongin D, Xestospongia sp., XeD
• Empirical Formula (Hill Notation): C₂₈H₅₀N₂O₃
• Molecular Weight: 462.71
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥90% (TLC)
• form: film
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: clear
• solubility: ethanol: 1 mg/mL; methanol: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A membrane-permeable, reversible blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 648 nM) that is less potent than XeC (Cat. No. 682160). Also displays a high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry1R).

A reversible, membrane-permeable blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 648 nM). Also displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1).

Biochem/physiol Actions

Cell permeable: no

Primary Target
IP3-mediated Ca2+

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 648 nM in blocking IP3-mediated Ca2+ release

Warning

Toxicity: Harmful (C)

Preparation Note

Sonication may be required to achieve complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gafni, J., et al. 1997. Neuron 19, 723.
Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
Nakagawa, M., et al. 1984. Tetrahedron Lett.25, 3227

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable