MilliporeSigma
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GF342

Sigma-Aldrich

LIF,
Human Recombinant Animal Free

All Photos(1)
Synonym(s):
Leukemia Inhibitory Factor, Emfilermin, MLPLI, HILDA, D-FACTOR
eCl@ss:
32160405
NACRES:
NA.75

impurities

<0.1 μg/mg protein endotoxin (<1 EU/μg)

Quality Level

100

UniProt accession no.

P15018

shipped in

dry ice

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GF342

LIF,
Human Recombinant Animal Free

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Human Recombinant Animal Free

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TWEAK,
Human Recombinant Animal Free

impurities

<0.1 μg/mg protein endotoxin (<1 EU/μg)

impurities

<0.1 μg/mg protein endotoxin (<1 EU/μg)

impurities

<0.1 μg/mg protein endotoxin (<1 EU/μg)

impurities

<0.1 μg/mg protein endotoxin (<1 EU/μg)

UniProt accession no.

P15018

UniProt accession no.

Q9Y275

UniProt accession no.

P21781

UniProt accession no.

O43508

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

General description

LIF is a pleiotrophic factor produced by multiple cell types including T cells, myelomoncytic lineages, fibroblasts, liver, heart and melanoma. LIF promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of adipogenesis by inhibiting the lipoprotein lipase in adipocytes. While human LIF is active on mouse cells and is widely used in the maintenance of murine ESC to prevent spontaneous differentiation, mouse LIF is not active on human cells due to its inability to bind to the human LIF receptor.
Recombinant human LIF is a 19.6 kDa protein containing 180 amino acids residues including three disulfide bonds.

Quality

Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤0.1 ng/ml, corresponding to a specific activity of ≥1 x 10^7 units/mg.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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