HTS094RTA
Ready-to-Assay GAL1 Galanin Receptor Frozen Cells
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$1,080.00
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About This Item
$1,080.00
description
Cell line type: GPCR Cell Lines
GPCR Class A
protein target GAL1
Quality Level
technique(s)
calcium flux assay: suitable
detection method
fluorometric
General description
Galanin is a 29-30 amino acid peptide originally purified from intestine but later found to be abundant in the CNS. A family of 3 GPCRs, GAL1, GAL2 and GAL3, bind to galanin and mediate its biological effects. GAL1 couples to Gi/o to decrease intracellular cAMP levels (Wang et al., 1998). Galanin and its receptors have been implicated in pain, cognition, seizure activity, depression and drug addiction (Hökfelt, 2005). In particular, GAL1 mediates the anticonvulsant activity of galanin. Mice lacking GAL1 are affected by spontaneous seizures, and have increased susceptibility to seizures induced by lithium-pilocarpine treatment and electrical perforant path stimulation (McColl et al., 2006; Mazarati et al., 2004). Millipore′s cloned human GAL1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant GAL1 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists, antagonists and modulators at GAL1.
Components
Disclaimer
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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