Reactive with human c-erB-3. In normal tissues, c-erB-3 is found in non-dividing differentiated epithelial cells, neurons, and hepatocytes. In abnormal tissues, c-erB-3 is found in 80% of GI tract tumors and 20% of breast cancers.
Immunogen
Epitope: cytoplasmic domain
Synthetic peptide corresponding to a site on the cytoplasmic domain of the human c-erbB-3 oncoprotein
Application
Detect c-erbB-3 using this Anti-c-erbB-3 Antibody, cytoplasmic domain, clone RTJ2 validated for use in ELISA, IH, IP & WB.
Research Category Signaling
Research Sub Category Growth Factors & Receptors
Western blot
ELISA
Immunoprecipitation
Immunohistochemistry
Optimal working dilutions must be determined by end user.
Physical form
Format: Purified
Liquid in PBS, containing azide as a preservative.
Storage and Stability
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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British journal of cancer, 78(10), 1385-1390 (1998-11-21)
Expression of c-erbB3 protein was investigated in 104 primary breast carcinomas comprising nine comedo ductal carcinoma in situ (DCIS), 91 invasive ductal carcinomas and four invasive lobular carcinomas using two monoclonal antibodies, RTJ1 and RTJ2. Of the 91 invasive ductal
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