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NXF-10

Millipore

Natrix® Q Pilot

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Synonym(s):
Natrix® Q Membrane Adsorber
eCl@ss:
32011308

ligand

quaternary amine

Quality Level

description

Natrix® Q Pilot

product line

Natrix®

parameter

75-375 mL/min flow rate

bed H

0.5 mm

bed volume

15 mL

matrix active group

Macroporous polymer

pore size

0.4 μm pore size

capacity

3 g binding capacity (BSA)(per device)

separation technique

strong anion exchange

shipped in

ambient

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This Item
NXF-20NXF-50NATQ02525
Natrix® Q Pilot

Millipore

NXF-10

Natrix® Q Pilot

Natrix® Q Process 150

Millipore

NXF-20

Natrix® Q Process 150

Natrix® Q Process 600

Millipore

NXF-50

Natrix® Q Process 600

product line

Natrix®

product line

Natrix®

product line

Natrix®

product line

-

parameter

75-375 mL/min flow rate

parameter

0.6-3 L/min flow rate

parameter

2.3-11.5 L/min flow rate

parameter

6-10 mL/min water flow rate (at 15 psi)

pore size

0.4 μm pore size

pore size

0.4 μm pore size

pore size

0.4 μm pore size

pore size

0.4 μm (nominal)

capacity

3 g binding capacity (BSA)(per device)

capacity

23 g binding capacity (BSA)(per device

per device)

capacity

92 g binding capacity (BSA)(per device)

capacity

-

separation technique

strong anion exchange

separation technique

strong anion exchange

separation technique

strong anion exchange

separation technique

-

General description

Strong anion exchange chromatography membrane design to purify biomolecules with a high density of quaternary amine ligand the enables fast flow rates and high throughput at high loads while maintaining excellent impurity reduction
With a revolutionary three-dimensional macroporous hydrogel structure that provides a high density of binding sites and rapid mass transfer, Natrix®(Q)chromatography membranes deliver binding capacity that exceeds resin-based columns with fast flow rates typical of traditional membrane adsorbers.This combination of performance and speed in a single-use, plug-and-play device format enables low-risk, scalable solutions for efficient biomolecule purification.

Natrix®(Q)chromatography membrane is a high productivity strong anion exchange membrane designed for biomolecule purification. The unique Natrix®(Q)chromatography membrane is a porous polyacrylamide hydrogel containing a high density of pendant quaternary ammonium(Q) binding groups that are directly polymerized within the an inert, macroporous membrane scaffold. The interconnected pore structure and high functional group density enables fast flow rates (seconds of residence time) with impressive throughput to extremely high loads while maintaining excellent impurity reduction across a wide range of buffer conditions. The Natrix®(Q)chromatography membrane design delivers improvements in productivity, flexibility, and process robustness and economics for any bioprocess design. The Natrix®(Q) Pilot is an intermediate scale device, intended to verify and adjust operating parameters. The Pilot may be used for small-scale clinical and commercial manufacturing.
mAb nominal polishing capacity: 150 g

Membrane configuration: Pleated

1 device per package

Features and Benefits

Natrix® Q membrane adsorber provides users with:

  • High density of quaternary amine binding sites enabling rapid mass transfer
  • High binding capacity even at fast flow rates
  • Combination of performance and speed in, single use, plug-and-play device format enables low risk, scalable solutions for efficient biomolecule purification.

Packaging

Double bagged

Legal Information

NACONNECT is a trademark of Merck KGaA, Darmstadt, Germany
NATRIFLO is a trademark of Merck KGaA, Darmstadt, Germany
NATRIX is a registered trademark of Merck KGaA, Darmstadt, Germany

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Computational and structural biotechnology journal, 14, 309-318 (2016-08-30)
The current processing paradigm of large manufacturing facilities dedicated to single product production is no longer an effective approach for best manufacturing practices. Increasing competition for new indications and the launch of biosimilars for the monoclonal antibody market have put
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Biotechnology progress, 31(4), 974-982 (2015-05-29)
Protein A chromatography is widely employed for the capture and purification of monoclonal antibodies (mAbs). Because of the high cost of protein A resins, there is a significant economic driving force to seek new downstream processing strategies. Membrane chromatography has

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