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Hydrogen chloride - 1-butanol solution

~3 M in 1-butanol, for GC derivatization, LiChropur

CAS Number:
Beilstein:
1098214
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

grade

for GC derivatization

form

solution

quality

LiChropur

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

concentration

~3 M in 1-butanol

technique(s)

gas chromatography (GC): suitable

density

0.87 g/mL at 20 °C

storage temp.

2-8°C

SMILES string

Cl

InChI

1S/ClH/h1H

InChI key

VEXZGXHMUGYJMC-UHFFFAOYSA-N

General description

Acylation, an alternative to silylation, is the conversion of compounds that contain active hydrogens (-OH, -SH and -NH) into esters, thioesters, and amides through the action of a carboxylic acid or derivative. The presence of a carbonyl group adjacent to the halogenated carbons enhances electron capture detector (ECD) response. Acylation has many benefits:
  • It improves the stability of compounds by protecting unstable groups.
  • It may confer volatility on substances such as carbohydrates or amino acids, which have so many polar groups that they are non-volatile and normally decompose on heating.
  • It assists in separations not possible with underivatized compounds.
  • Compounds are detectable at very low levels with an ECD.

Hydrogen chloride-1-butanol is a reagent utilized to form fragmentation-directing derivatives for GC/MS analysis.

Application

Hydrogen chloride - 1-butanol solution has been used for butylation of amino acids during blood sample analysis for determination of ethylenediaminetetraacetic acid using mass spectrometry.

Other Notes

Reagent for the esterification of amino acids and carnites for GC-MS analysis

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Met. Corr. 1 - Skin Irrit. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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