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NIST8671

NISTmAb, Humanized IgG1k Monoclonal Antibody

NIST® SRM® 8671

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1 EA
$2,310.00

$2,310.00

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1 EA
$2,310.00

About This Item

UNSPSC Code:
41116107
NACRES:
NA.41

$2,310.00

Please contact Customer Service for Availability
Request a Bulk Order

antibody product type

primary antibodies

grade

certified reference material

form

liquid

manufacturer/tradename

NIST®

technique(s)

UV/Vis spectroscopy: suitable
liquid chromatography (LC): suitable
mass spectrometry (MS): suitable

format

matrix material

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NIST8671

NISTmAb, Humanized IgG1k Monoclonal Antibody

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grade

certified reference material

grade

certified reference material

grade

-

grade

certified reference material

manufacturer/tradename

NIST®

manufacturer/tradename

NIST®

manufacturer/tradename

-

manufacturer/tradename

NIST®

format

matrix material

format

matrix material

format

-

format

-

form

liquid

form

liquid

form

buffered aqueous solution

form

liquid

antibody product type

primary antibodies

antibody product type

-

antibody product type

primary antibodies

antibody product type

-

technique(s)

UV/Vis spectroscopy: suitable

technique(s)

mass spectrometry (MS): suitable

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 0.5-1 μg/mL using HeLa total cell extract

technique(s)

-

General description

NISTmAb, Humanized IgG1k Monoclonal Antibody is a recombinant antibody expressed in murine suspension culture. It is a homodimer with two identical light chains and two identical heavy chains linked through inter- and intra- chain disulfide bonds with a molecular weight of 150 kDa. The protein possesses a low abundance of post-translational modifications including methionine oxidation, deamidation, and glycation. This humanized monoclonal antibody also has N-terminal pyroglutamination, C-terminal lysine clipping, and glycosylation of the heavy chains.

A unit of RM 8671 consists of one internal-threaded polypropylene cryovial containing 800 µL of 10 mg/mL NIST IgG1κ monoclonal antibody (NISTmAb) in 12.5 mmol/L L-histidine, 12.5 mmol/L L-histidine HCl (pH 6.0).

SRM 8671_Cert

SRM 8671_SDS

Application

NISTmAb, Humanized IgG1k Monoclonal Antibody has been used as a standard for testing de novo sequencing algorithms on bottom-up mass spectrometry.[1]This reference material (RM) is primarily intended for evaluating the performance of methods for determining physiochemical and biophysical attributes of monoclonal antibodies. It also provides a representative test molecule for developing novel technology in therapeutic protein characterization. Other potential uses include:
  • system suitability tests
  • establishing method or instrument performance and variability
  • comparing changing analytical test methods
  • assisting in method qualification

Analysis Note

NIST8671 is intended for research use. It is not intended for animal or human consumption, clinical testing or therapeutic use.

Other Notes

  • RM 8671 is intended for research use.
  • Details on expiration, storage, safety, usage, and source are provided in the NIST certificate. 
  • Information on biomaterials, disposal, and transport is available in the SDS.

Legal Information

NIST is a registered trademark of National Institute of Standards and Technology
SRM is a registered trademark of National Institute of Standards and Technology

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Description
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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. How many mg are in 1 unit of NIST8671 - NISTmAb, Humanized IgG1k Monoclonal Antibody?

    1 answer

    1. As mentioned in the 'DESCRIPTION' section, one unit or vial of RM 8671 contains 800 µL of 10 mg/mL NIST IgG1k monoclonal antibody (NISTmAb) in 12.5 mmol/L L-histidine, 12.5 mmol/L L-histidine HCl (pH 6.0).

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