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NIST8671

NISTmAb, Humanized IgG1k Monoclonal Antibody

NACRES:
NA.41

antibody product type

primary antibodies

grade

certified reference material

description

NIST® RM 8671

manufacturer/tradename

NIST®

application(s)

pharmaceutical (small molecule)

format

matrix material

General description

This RM is primarily intended for use in evaluating the performance of methods for determining physiochemical and biophysical attributes of monoclonal antibodies. It also provides a representative test molecule for the development of novel technology in therapeutic protein characterization.

Other potential uses include system suitability tests, establishing method or instrument performance and variability, comparing changing analytical test methods, and assisting in method qualification.

Application

NISTmAb, Humanized IgG1k Monoclonal Antibody has been used as a standard for testing de novo sequencing algorithm on bottom-up mass spectrometry.

Packaging

1 ea

Biochem/physiol Actions

NISTmAb, Humanized IgG1k Monoclonal Antibody is a recombinant antibody expressed in murine suspension culture. It is a homodimer with two identical light chains and two identical heavy chains linked through inter- and intra- chain disulfide bonds with a molecular weight of 150 kDa. The protein possesses low abundance post-translational modifications including methionine oxidation, deamidation, and glycation. The molecule also has N-terminal pyroglutamination, C-terminal lysine clipping, and glycosylation of the heavy chains.

Analysis Note

NIST8671 is intended for research use. It is not intended for animal or human consumption, clinical testing or therapeutic use.

Legal Information

NIST is a registered trademark of National Institute of Standards and Technology

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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