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Sodium bicarbonate

puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.7%

Sodium hydrogen carbonate
Linear Formula:
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


ACS reagent
puriss. p.a.


reag. Ph. Eur.






≤0.0005% ammonium (NH4)
≤0.003% S-compounds (as SO4)
≤0.005% I red. matters (as SO2)
≤0.015% in water insoluble matters


≤8.6 (20 °C, 5%)

pKa (25 °C)

(1) 6.37, (2) 10.25 (carbonic acid)


H2O: 0.5 g/10 mL, clear, colorless
water: soluble 50 g/L


2.16 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤10 mg/kg
phosphate (PO43-): ≤10 mg/kg

cation traces

As: 2 ppm (MHS-AAS)
Ca: ≤100 ppm
Cd: ≤5 ppm
Co: ≤50 ppm
Cu: ≤5 ppm
Fe: ≤5 ppm
K: ≤50 ppm
Mg: ≤50 ppm
Ni: ≤50 ppm
Pb: ≤5 ppm
Zn: ≤5 ppm
heavy metals: ≤5 ppm (by ICP-OES)


complies for appearance of solution

SMILES string




InChI key


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General description

Sodium bicarbonate is widely used as a physiological buffer. The pKa for bicarbonate ↔ carbonic acid reaction is 6.37. The pKa for bicarbonate ↔ carbonate reaction is 10.25.


Sodium bicarbonate may be used to maintain 7.4pH in Iscove′s modified Dulbecco′s medium for growth of murine hybridoma cell culture. It may be employed as a component of RPMI-1640 liquid medium in a study.

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Intravenous sodium bicarbonate has been proposed to reduce the risk for contrast-induced nephropathy (CIN). To determine the effect of sodium bicarbonate on the risk for CIN. MEDLINE, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from 1950 to
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