The enzyme has been used for an assay to detect the amount of Tf1 RNA that is protected from degradation by the nuclease, Benzonase. The Tf1 element of Schizosaccharomyces pombe
is a long terminal repeat-containing retrotransposon that encodes functional protease, reverse transcriptase, and integrase proteins.
It has also been used in the fractionation of nuclear pellet and nuclear extract obtained from cell lysates.
Used for the removal of nucleic acid from protein samples.