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MilliporeSigma

EHU109221

MISSION® esiRNA

targeting human TARDBP

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20 μG

$337.00

50 μG

$598.00

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About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

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description

Powered by Eupheria Biotech

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

ATGCCGAACCTAAGCACAATAGCAATAGACAGTTAGAAAGAAGTGGAAGATTTGGTGGTAATCCAGGTGGCTTTGGGAATCAGGGTGGATTTGGTAATAGCAGAGGGGGTGGAGCTGGTTTGGGAAACAATCAAGGTAGTAATATGGGTGGTGGGATGAACTTTGGTGCGTTCAGCATTAATCCAGCCATGATGGCTGCCGCCCAGGCAGCACTACAGAGCAGTTGGGGTATGATGGGCATGTTAGCCAGCCAGCAGAACCAGTCAGGCCCATCGGGTAATAACCAAAACCAAGGCAACATGCAGAGGGAGCCAAACCAGGCCTTCGGTTCTGGAAATAACTCTTATAGTGGCTCTAATTCTGGTGCAGCAATTGGTTGGGGATCAGCATCCAATGCAGGGTCGGGCAGTGGTTTTAATGGAGGCTTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGGAATGTAGAC

Ensembl | human accession no.

ENSG00000120948

NCBI accession no.

NM_007375

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... TARDBP(23435), TARDBP(23435)

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MISSION® esiRNA targeting human TARDBP

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MISSION® esiRNA

MISSION® esiRNA targeting human SSBP2

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MISSION® esiRNA targeting human WDR7

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MISSION® esiRNA

MISSION® esiRNA targeting human QPRT

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MISSION® esiRNA

esiRNA cDNA target sequence

ATGCCGAACCTAAGCACAATAGCAATAGACAGTTAGAAAGAAGTGGAAGATTTGGTGGTAATCCAGGTGGCTTTGGGAATCAGGGTGGATTTGGTAATAGCAGAGGGGGTGGAGCTGGTTTGGGAAACAATCAAGGTAGTAATATGGGTGGTGGGATGAACTTTGGTGCGTTCAGCATTAATCCAGCCATGATGGCTGCCGCCCAGGCAGCACTACAGAGCAGTTGGGGTATGATGGGCATGTTAGCCAGCCAGCAGAACCAGTCAGGCCCATCGGGTAATAACCAAAACCAAGGCAACATGCAGAGGGAGCCAAACCAGGCCTTCGGTTCTGGAAATAACTCTTATAGTGGCTCTAATTCTGGTGCAGCAATTGGTTGGGGATCAGCATCCAATGCAGGGTCGGGCAGTGGTTTTAATGGAGGCTTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGGAATGTAGAC

esiRNA cDNA target sequence

CAAGAGGAATGGTGCCCTTAGGACCACAGAACTATGGAGGTGCAATGAGACCCCCACTGAATGCTTTAGGTGGCCCTGGAATGCCTGGAATGAACATGGGTCCAGGTGGTGGTAGACCTTGGCCAAACCCAACAAATGCCAATTCAATACCATACTCCTCAGCATCTCCTGGGAATTATGTAGGTCCTCCAGGAGGTGGAGGGCCACCAGGAACACCCATCATGCCTAGTCCAGCAGATTCAACCAACTCTGGTGATAACATGTATACTTTAATGAATGCAGTACCTCCTGGACCTAACAGACCTAATTTTCCAATGGGTCCTGGGTCAGATGGTCCCATGGGTGGATTAGGAGGAATGGAGTCACATCACATGAATGGCTCTTTAGGCTCAGGAGATATGGACAGTATTTCCAAGAATTCTCCCAATAATATGAGCCTGAGTAATCAACCG

esiRNA cDNA target sequence

TCAAAGTCTAGGAACAAACATTGGTTATTTCACTGAAACAGATTTTTAAAGAGCATATTAAGAAATTAAGACCATTAGATCATCTCTTTCATAATGATATGATGTTATTTCCATTGACGGCAAATCTATACTGTTCCTTGGTTTTAGAGTTGGGTATTCTTTCAAAAGTGAATTTAGGCACATGCATGTACATTGTATTTATAAAGATTATATATGTAGTTTCCAAGGAAGAAACAAAGACCTATACAGTTTAGACTTTATTTGTTTGGTGAACGTGCTGTTGTGTTTGGCATAGCTAGAGAAATGTAAGGTAAAAGGCTCACTTTGTTTTCCAGTGGGTCCAGAGTCTTCTCTATACCCAACATATGTTTACTTTATGAACTTAAATGGAAATTAATTTATTGTAGACTACATCTCTATTTGGAATGATGAGGTAAATGTATACCTTAGCATTTTCTTTAACAAAAATGTTCTGTGTGTCAGGAA

esiRNA cDNA target sequence

AAGGTGGAAGTGGAATGCAGCAGCCTGCAGGAGGCCGTGCAGGCAGCTGAGGCTGGTGCCGACCTTGTCCTGCTGGACAACTTCAAGCCAGAGGAGCTGCACCCCACGGCCACCGTGCTGAAGGCCCAGTTCCCGAGTGTGGCTGTGGAAGCCAGTGGGGGCATCACCCTGGACAACCTCCCCCAGTTCTGCGGGCCGCACATAGACGTCATCTCCATGGGGATGCTGACCCAGGCGGCCCCAGCCCTTGATTTCTCCCTCAAGCTGTTTGCCAAAGAGGTGGCTCCAGTGCCCAAAATCCACTAGTCCTAAACCGGAAGAGGATGACACCGGCCATGGGTTAACGTGGCTCCTCAGGACCCTCTGGGTCACACATCTTTAGGGTCAGTGGCCAATGGGGCACATTTGGCACTAGCTTGAGCCCAACTCTGGCTCTGCCACCTGCTGCTCCTGTGACCTGTCAGGGCTGACTTCACCTCTGCTCATCTCAGTTTCCTAATCTGTAAAATGGGTCTAATAAAGGATCAACCACATGGGGTTCTGCGGTGATAATGAGCAC

Ensembl | human accession no.

ENSG00000120948

Ensembl | human accession no.

ENSG00000145687

Ensembl | human accession no.

ENSG00000091157

Ensembl | human accession no.

ENSG00000103485

Gene Information

human ... TARDBP(23435), TARDBP(23435)

Gene Information

human ... SSBP2(23635), SSBP2(23635)

Gene Information

human ... WDR7(23335), WDR7(23335)

Gene Information

human ... QPRT(23475), QPRT(23475)

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

NCBI accession no.

NM_007375

NCBI accession no.

NM_012446

NCBI accession no.

NM_015285

NCBI accession no.

NM_014298

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Seiichi Nagano et al.
Acta neuropathologica, 140(5), 695-713 (2020-08-18)
Mislocalization and abnormal deposition of TDP-43 into the cytoplasm (TDP-43 proteinopathy) is a hallmark in neurons of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). However, the pathogenic mechanism of the diseases linked to TDP-43 is largely unknown. We
Michael E Ward et al.
The Journal of experimental medicine, 211(10), 1937-1945 (2014-08-27)
Frontotemporal dementia (FTD) is the most common cause of dementia in people under 60 yr of age and is pathologically associated with mislocalization of TAR DNA/RNA binding protein 43 (TDP-43) in approximately half of cases (FLTD-TDP). Mutations in the gene
Xiaowei Chen et al.
Protein & cell, 9(10), 848-866 (2017-09-28)
Aberrant regulation of miRNA genes contributes to pathogenesis of a wide range of human diseases, including cancer. The TAR DNA binding protein 43 (TDP-43), a RNA/DNA binding protein associated with neurodegeneration, is involved in miRNA biogenesis. Here, we systematically examined
Stephani A Davis et al.
Neurobiology of disease, 103, 154-162 (2017-04-19)
Although the main focus in Alzheimer's disease (AD) has been an investigation of mechanisms causing Aβ plaque deposition and tau tangle formation, recent studies have shown that phosphorylated TDP-43 pathology is present in up to 50% of sporadic cases. Furthermore
Pascual Torres et al.
Autophagy, 14(8), 1398-1403 (2018-06-19)
TARDBP (TAR DNA binding protein) is one of the components of neuronal aggregates in sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. We have developed a simple quantitative method to evaluate TARDBP splicing function that was applied to spinal
View All Related Papers

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