H4036

SAFC

L-Histidine monohydrochloride monohydrate

Synonym(s):
L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride
Empirical Formula (Hill Notation):
C6H9N3O2 · HCl · H2O
CAS Number:
Molecular Weight:
209.63
Beilstein/REAXYS Number:
4168261
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

biological source

non-animal source

assay

≥98.5%

form

powder

manufacturer/tradename

Ajinomoto

application(s)

cell culture | mammalian: suitable

impurities

endotoxin, heavy metals, residual solvents, tested

mp

254 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

Featured Industry

Pharmaceutical (small molecule)

foreign activity

cytotoxicity, tested

SMILES string

O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1

InChI key

CMXXUDSWGMGYLZ-XRIGFGBMSA-N

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General description

To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

Application

L-Histidine, an essential amino acid. It is used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. L-Histidine monohydrochloride monohydrate is a modified version of L-Histidine with improved solubility.

pictograms

Exclamation mark

signalword

Warning

hcodes

hazcat

Eye Irrit. 2

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 1

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Bakul Bhatnagar et al.
The journal of physical chemistry. B, 123(27), 5690-5699 (2019-07-02)
Protein/ice interactions are investigated by a novel method based on measuring the characteristic features of X-ray diffraction (XRD) patterns of hexagonal ice (Ih). Aqueous solutions of four proteins and other solutes are studied using high-resolution synchrotron XRD. Two pharmaceutical proteins...
Martin Maldonado et al.
Neurochemistry international, 85-86, 31-39 (2015-05-06)
The effect of reserpine on histamine (HA) and tele-methylhistamine (N(τ)-MHA) in hypothalamus and cortex of rats was analyzed and compared to catecholamines. IP injection of reserpine (5 mg/kg) confirmed the effectiveness of reserpine treatment on noradrenaline and dopamine levels. Our in-vitro...
Verena Saller et al.
Journal of pharmaceutical sciences, 104(4), 1440-1450 (2015-01-22)
In a typical manufacturing setup for biopharmaceutical drug products, the fill and dosing pump is placed after the final sterile filtration unit in order to ensure adequate dispensing accuracy and avoid backpressure peaks. Given the sensitivity of protein molecules, peristaltic...
Kristin Bjornsdottir-Butler et al.
Journal of food protection, 78(7), 1335-1342 (2015-07-22)
Recent developments in detection and enumeration of histamine-producing bacteria (HPB) have created powerful molecular-based tools to better understand the presence of spoilage bacteria and conditions, resulting in increased risk of scombrotoxin fish poisoning. We examined 235 scombrotoxin-forming fish from the...
Aldo Roda et al.
The Analyst, 139(24), 6494-6501 (2014-10-25)
Increasingly, smartphones are used as portable personal computers, revolutionizing communication styles and entire lifestyles. Using 3D-printing technology we have made a disposable minicartridge that can be easily prototyped to turn any kind of smartphone or tablet into a portable luminometer...

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