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H8041

Sigma-Aldrich

Interleukin-23 human

IL-23, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

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NACRES:
NA.77

biological source

human

Quality Level

recombinant

expressed in HEK 293 cells

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

≤2 ng/mL EC50

quality

endotoxin tested

mol wt

dimer 55 kDa (glycosylated)

packaging

pkg of 5X10 μg
pkg of 10 μg
pkg of 5 μg

technique(s)

cell culture | mammalian: suitable

impurities

≤1EU/mg

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... IL23A(51561)

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SCU0001I0523I2644
Sigma-Aldrich

Sigma-Aldrich

H8041

Interleukin-23 human

Interleukin-6 human recombinant, expressed in HEK 293 cells, suitable for cell culture

Sigma-Aldrich

SCU0001

Interleukin-6 human

Sigma-Aldrich

Sigma-Aldrich

I2644

Interleukin-2 human

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

assay

-

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

potency

≤2 ng/mL EC50

potency

0.2-2 ng/mL EC50

potency

≤0.2 ng/mL ED50

potency

≤700 EC50

mol wt

dimer 55 kDa (glycosylated)

mol wt

calculated mol wt 20.8 kDa (183 amino acids glycosylated protein)

mol wt

17.2 kDa

mol wt

15.5 kDa

General description

HumanKine interleukin-23 (IL-23) is expressed as a heterodimeric 55 kDa cytokine composed of two glycosylated and disulfide linked subunits (p40 cystine linked to p19). Production in human HEK 293 cells offers authentic glycosylation. Cytokines produced in Sf9 or Sf21 cells have post-translational modifications, which are not human-like.

Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated dendritic cells and macrophages. It is a 20.7kDa protein with 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.

Biochem/physiol Actions

Interleukin-23 (IL-23) plays a major role in cutaneous immune-mediated inflammatory diseases like psoriasis, allergic contact dermatitis and atopic dermatitis. It is involved in cellular immunity, driving the expansion, stabilization and survival of Th17 cells.

Analysis Note

The specific activity was determined by the dose-dependent secretion of h-IFN-γ or IL-8 from human PBMC.

Legal Information

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Storage Class Code

11 - Combustible Solids

WGK

WGK 1


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Expression of IL-23/Th17-related cytokines in basal cell carcinoma and in the response to medical treatments
Cristina P, et al.
PLoS ONE, 12(8), e0183415-e0183415 (2017)
IL23A (interleukin 23, alpha subunit p19)
Norimitsu I.
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 15(2) (2011)

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