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I0531

Sigma-Aldrich

Interleukin-18 from rat

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

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MDL number:
NACRES:
NA.32

biological source

rat

Quality Level

recombinant

expressed in E. coli

Assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

10-60 ng/mL ED50

mol wt

predicted mol wt ~18.4 kDa

packaging

pkg of 25 μg

impurities

endotoxin, tested

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

rat ... Il18(29197)

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expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

>97% (SDS-PAGE)

assay

>97% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

form

lyophilized powder

form

buffered aqueous solution

form

lyophilized powder

form

lyophilized powder

mol wt

predicted mol wt ~18.4 kDa

mol wt

predicted mol wt ~22 kDa

mol wt

predicted mol wt 13.5 kDa

mol wt

~18 kDa

packaging

pkg of 25 μg

packaging

pkg of 10 and 50 μg

packaging

pkg of 5 μg

packaging

pkg of 5 μg

Biochem/physiol Actions

Interleukin 18, also known as interferon-γ-inducing factor (IGIF) and IL-1γ, is a proinflammatory cytokine. It is an inducer of IFN-γ and Th1 (T cell helper type 1) responses (cell differentiation, cell-mediated cytotoxicity and inflammation). IL-18 induces the migration of microvascular endothelial cells.

Physical form

Lyophilized from 20 mM Tris , 500 mM NaCl, 0.5 mM EDTA, 1 mM TCEP, 0.05% (w/v) PEG8000 pH 8.0 with 5% Trehalose,and 50 μg BSA per μg IL-18

Analysis Note

The biological activity is measured by its ability to induce mouse IFN-γ production by activated mouse T cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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