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I7908

Sigma-Aldrich

Interleukin-2 human

recombinant, expressed in Pichia pastoris, suitable for cell culture

Synonym(s):
IL-2, Interleukin-2, T-cell growth factor
MDL number:
NACRES:
NA.75

biological source

human

Quality Level

recombinant

expressed in Pichia pastoris

Assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

mol wt

predicted mol wt ~15 kDa

packaging

pkg of 10KU

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... IL2(3558)

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biological source

human

biological source

human

biological source

human

biological source

human

recombinant

expressed in Pichia pastoris

recombinant

expressed in HEK 293 cells

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

assay

≥98% (SDS-PAGE and HPLC)

assay

≥95% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

mol wt

predicted mol wt ~15 kDa

mol wt

dimer 18-25 kDa (glycosylated)

mol wt

14.9 kDa (containing 129 amino acid residues)

mol wt

calculated mol wt 20.8 kDa (183 amino acids glycosylated protein)

packaging

pkg of 10KU

packaging

pkg of 10 μg

packaging

pkg of 5 and 50 μg

packaging

vial of ≥10 μg

Application

Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs.

Biochem/physiol Actions

Interleukin 2 (IL2) is a pro-inflammatory cytokine. It consists of three subunits, in which the β subunit is important for receptor mediated signaling. IL2 enhances the development of T regulatory cells and plays a crucial role in antitumor immunity.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Physical form

Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.

Analysis Note

The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

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