We have not done any such testing, but the following references may be helpful: https://jpet.aspetjournals.org/cgi/content/abstract/320/3/1013, https://molpharm.aspetjournals.org/cgi/reprint/66/1/187.
L9908
LY-294,002 hydrochloride
from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor
Synonym(s):
2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
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1 MG
$116.00
5 MG
$277.00
About This Item
Empirical Formula (Hill Notation):
C19H17NO3 · HCl
CAS Number:
Molecular Weight:
343.80
UNSPSC Code:
12352207
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Product Name
LY-294,002 hydrochloride, solid, ≥98% (HPLC)
SMILES string
O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
InChI
1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChI key
CZQHHVNHHHRRDU-UHFFFAOYSA-N
biological source
microbial (Staphylococcus roseus)
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: >5 mg/mL
H2O: insoluble
storage temp.
2-8°C
Quality Level
Related Categories
1 of 4
This Item | L1170 | 440202 | SML0693 |
|---|---|---|---|
| form solid | form powder | form solid | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: >5 mg/mL, H2O: insoluble | solubility DMSO: >20 mg/mL | solubility DMSO: 20 mg/mL, ethanol: soluble | solubility DMSO: 10 mg/mL, clear |
| color white to off-white | color off-white | color off-white | color orange-red |
Application
Biochem/physiol Actions
Specific cell permeable phosphatidylinositol 3-kinase inhibitor.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
General description
LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K).[5] LY-294,002 inhibits nuclear factor kappa B signaling in macrophages.[6] It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric[7] and nasopharyngeal cancer cells.[8] LY-294,002 modulates action potential repolarization and improves myocyte contractility.[9]
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
Walker EH, et al.
Molecular Cell, 6(4), 909-919 (2000)
miR-126 suppresses epithelial-to-mesenchymal transition and metastasis by targeting PI3K/AKT/Snail signaling of lung cancer cells
Jia Z, et al.
Oncology Letters, 15(5), 7369-7375 (2018)
G J Brunn et al.
The EMBO journal, 15(19), 5256-5267 (1996-10-01)
The immunosuppressant, rapamycin, inhibits cell growth by interfering with the function of a novel kinase, termed mammalian target of rapamycin (mTOR). The putative catalytic domain of mTOR is similar to those of mammalian and yeast phosphatidylinositol (PI) 3-kinases. This study
Regulation of PKCbeta levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis
Morganti C, et al.
International Journal of Obesity, 1-1 (2018)
C J Vlahos et al.
Journal of immunology (Baltimore, Md. : 1950), 154(5), 2413-2422 (1995-03-01)
Neutrophils contain a multicomponent NADPH oxidase system that is involved in the production of microbicidal oxidants. Stimulation of human neutrophils with the peptide FMLP activates this respiratory burst enzyme to produce superoxide and also has been shown to result in
Articles
We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
Discover Bioactive Small Molecules for Lipid Signaling Research
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Can I use Product L9908, LY-294,002 hydrochloride, in conjugation with Wortmannin?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the solution stability in DMSO for Product L9908, LY-294,002 hydrochloride?
1 answer-
After reconstitution in DMSO, aliquot and freeze the stock solution at -20 °C. DMSO stock solutions are stable for at least 1 month at -20 °C.
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What is the recommended concentration for using Product L9908, LY-294,002 hydrochloride?
1 answer-
One can use this product at 50 uM concentration.
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