RAB0309

Mouse IL-6 ELISA Kit

Name: Mouse IL-6 ELISA Kit
Brand: SIGMA
Price: 770 CAD

for cell and tissue lysates

Synonym(s):

B-cell stimulatory factor 2, CTL differentiation factor, Hybridoma growth factor, IFN-beta-2, IL-6

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1 KIT

$770.00

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About This Item

NACRES:

NA.32

UNSPSC Code:

41116158

Key Documents

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Product Name

Mouse IL-6 ELISA Kit, for cell and tissue lysates

species reactivity

mouse

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable
capture ELISA: suitable

input

sample type tissue lysate
sample type cell lysate

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 2 pg/mL
standard curve range: 0.82-600 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Il6(24498)

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Enzyme-Linked Immunosorbent Assay (ELISA) Kits

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This Item	RAB0308	RAB0287	RAB0317
Sigma-Aldrich RAB0309 Mouse IL-6 ELISA Kit	Sigma-Aldrich RAB0308 Mouse IL-6 ELISA Kit	Sigma-Aldrich RAB0287 Mouse IL-2 ELISA Kit	Sigma-Aldrich RAB0317 Mouse IL-7 ELISA Kit
Gene Information mouse ... Il6(24498)	Gene Information mouse ... Il6(24498)	Gene Information mouse ... Il2(16183)	Gene Information mouse ... Il7(16196)
species reactivity mouse	species reactivity mouse	species reactivity mouse	species reactivity mouse
assay range inter-assay cv: <12% intra-assay cv: <10% sensitivity: 2 pg/mL standard curve range: 0.82-600 pg/mL	assay range inter-assay cv: <12% intra-assay cv: <10% sensitivity: 2 pg/mL standard curve range: 0.82-600 pg/mL	assay range inter-assay cv: <12% intra-assay cv: <10% sensitivity: 1 pg/mL standard curve range: 0.625-40 pg/mL	assay range inter-assay cv: <12% intra-assay cv: <10% sensitivity: 10 pg/mL standard curve range: 8.23-6000 pg/mL
input sample type tissue lysate sample type cell lysate	input sample type plasma sample type cell culture supernatant(s) sample type serum	input sample type serum sample type cell culture supernatant(s) sample type plasma	input sample type serum sample type cell culture supernatant(s) sample type plasma
detection method colorimetric	detection method colorimetric	detection method colorimetric	detection method colorimetric
technique(s) ELISA: suitable, capture ELISA: suitable	technique(s) ELISA: suitable, capture ELISA: suitable	technique(s) ELISA: suitable, capture ELISA: suitable	technique(s) ELISA: suitable, capture ELISA: suitable

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Application

Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Mouse IL-6 ELISA Kit has been used to measure the concentration of interleukin-6 (IL-6) in cell culture supernatants.[1]

Biochem/physiol Actions

IL-6 (interleukin 6) is a pleiotropic cytokine that mediates immune and inflammatory responses.[2] It synergizes with IL-3 in megakaryocyte development and platelet production.[3] IL-6 is associated with various autoimmune and inflammatory diseases.[2] High levels of IL-6 are present in the synovial fluid from rheumatoid arthritis patients. It is also linked with chronic inflammatory proliferative disease and B cell malignancy, Castleman′s disease and plasmacytoma/multiple myeloma.[2]

General description

The Mouse IL-6 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of mouse IL-6 cell lysate and tissue lysate.

IL-6 (interleukin 6) signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130 (membrane glycoprotein 130).[2] The gene IL-6 is mapped to human chromosome 7p15.3.[4]

Immunogen

Recombinant Mouse IL-6

pictograms

GHS05

signalword

Warning

hcodes

H290

pcodes

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

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Metabolic induction of trained immunity through the mevalonate pathway.

Bekkering S, et al.

Cell, 172(1), 135-146 (2018)

Granzyme K Expressed by Classically Activated Macrophages Contributes to Inflammation and Impaired Remodeling.

Christopher T Turner et al.

The Journal of investigative dermatology, 139(4), 930-939 (2018-11-06)

Granzyme K (GzmK), traditionally described as a pro-apoptotic, granule-secreted serine protease, has been proposed to promote inflammation. Found at low levels in the plasma of healthy individuals, GzmK is markedly elevated in response to sepsis and infection. In this study

Interleukin-6: discovery of a pleiotropic cytokine.

Kishimoto T.

Arthritis Research & Therapy, 8(2), S2-S2 (2006)

Ciba Foundation Symposium (1992)

Common variants in genes that mediate immunity and risk of multiple myeloma.

Brown E E, et al.

International Journal of Cancer. Journal International Du Cancer, 120(12), 2715-2722 (2007)

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