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05030

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Ningjing Zou et al.
Journal of experimental & clinical cancer research : CR, 34, 70-70 (2015-07-25)
The role of human papillomavirus (HPV) may be involved in the development of esophageal cancer (EC) and the polymorphic immune response gene transporter associated with antigen processing (TAP) may be involved in HPV persistence and subsequent cancer carcinogenesis. The current
Nazanine Modjtahedi et al.
Cell cycle (Georgetown, Tex.), 14(17), 2743-2747 (2015-07-17)
Hypomorphic mutation of apoptosis-inducing factor (AIF) in the whole body or organ-specific knockout of AIF compromises the activity of respiratory chain complexes I and IV, as it confers resistance to obesity and diabetes induced by high-fat diet. The mitochondrial defect
Florencia A Ficarra et al.
PloS one, 10(5), e0125516-e0125516 (2015-05-12)
Xanthomonas citri subsp. citri colonizes its hosts through the trafficking of effector proteins to the plant cell by the type III protein secretion system. In X. citri subsp. citri, as in other plant pathogens, the hrp cluster encodes the type
Tanjina Kader et al.
Atherosclerosis, 237(2), 725-733 (2014-12-03)
D-ribose-L-cysteine (ribose-cysteine) is a cysteine analogue designed to increase the synthesis of glutathione (GSH). GSH is a cofactor for glutathione peroxidase (GPx), the redox enzyme that catalyses the reduction of lipid peroxides. A low GPx activity and increased oxidised lipids
Mathieu Fiore et al.
The Journal of thoracic and cardiovascular surgery, 148(6), 3119-3125 (2014-09-13)
This study evaluated platelet function for an extended period of time in patients with a HeartMate II continuous-flow left ventricular assist device (Thoratec Corporation, Pleasanton, Calif) with light transmission aggregometry and investigated the potential role of this test in clinical
Leticia Martínez-Caro et al.
Shock (Augusta, Ga.), 44(1), 36-43 (2015-04-22)
Mechanisms contributing to pulmonary and systemic injury induced by high tidal volume (VT) mechanical ventilation are not well known. We tested the hypothesis that increased peroxynitrite formation is involved in organ injury and dysfunction induced by mechanical ventilation. Male Sprague-Dawley
Marion Lavergne et al.
FEBS open bio, 3, 291-301 (2013-08-02)
Tissue factor pathway inhibitor-2 (TFPI-2) is a potent inhibitor of plasmin, a protease which is involved in tumour progression by activating (MMPs). This therefore makes TFPI-2 a potential inhibitor of invasiveness and the development of metastases. In this study, low
Pete Gagnon et al.
Journal of chromatography. A, 1374, 145-155 (2014-12-08)
Chromatin heteroaggregates comprising nucleosomal arrays, DNA, histone and non-histone host cell proteins contributed 28% of the host contaminant mass in an IgG cell culture harvest. A subset comprising soluble particles of 50-400nm was retained through its histone component by an
Rebecca Skerrett et al.
The Journal of biological chemistry, 290(35), 21591-21602 (2015-07-15)
Alzheimer disease (AD) is characterized by the extracellular accumulation of amyloid β (Aβ), which is accompanied by a robust inflammatory response in the brain. Both of these pathogenic processes are regulated by nuclear receptors, including the liver X receptors (LXRs)
Brett Deml et al.
PLoS genetics, 11(2), e1005002-e1005002 (2015-02-27)
Ocular coloboma results from abnormal embryonic development and is often associated with additional ocular and systemic features. Coloboma is a highly heterogeneous disorder with many cases remaining unexplained. Whole exome sequencing from two cousins affected with dominant coloboma with microcornea
Jennifer A Fraser et al.
Journal of molecular biology, 427(8), 1728-1747 (2014-12-30)
Mouse double minute 2 (MDM2) has a phosphorylation site within a lid motif at Ser17 whose phosphomimetic mutation to Asp17 stimulates MDM2-mediated polyubiquitination of p53. MDM2 lid deletion, but not Asp17 mutation, induced a blue shift in the λ(max) of
Ji Hyun Shin et al.
Biochemical and biophysical research communications, 460(2), 428-433 (2015-03-23)
Previously, we showed that BIX-01294 treatment strongly activates autophagy. Although, the interplay between autophagy and ciliogenesis has been suggested, the role of autophagy in ciliogenesis is controversial and largely unknown. In this study, we investigated the effects of autophagy induced
Kelly E Miller et al.
The Journal of cell biology, 209(2), 211-220 (2015-04-22)
Linker histone H1 is required for mitotic chromosome architecture in Xenopus laevis egg extracts and, unlike core histones, exhibits rapid turnover on chromatin. Mechanisms regulating the recruitment, deposition, and dynamics of linker histones in mitosis are largely unknown. We found
Rachida Mersni-Achour et al.
Microbiology (Reading, England), 161(Pt 5), 997-1007 (2015-02-24)
Vibrio tubiashii is a marine pathogen isolated from larval and juvenile bivalve molluscs that causes bacillary necrosis. Recent studies demonstrated the isolation of this species in a French experimental hatchery/nursery affecting Crassostrea gigas spat in 2007. Here, using larvae of
Petra Vychytilova-Faltejskova et al.
Diagnostic pathology, 10, 38-38 (2015-04-25)
Pancreatic ductal adenocarcinoma is an aggressive malignancy with late presentation, metastatic potential and very poor prognosis. Therefore, there is an urgent need for novel diagnostic and prognostic biomarkers. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. Altered expression
Mariana Portovedo et al.
PloS one, 10(3), e0119850-e0119850 (2015-03-19)
Autophagy is an important process that regulates cellular homeostasis by degrading dysfunctional proteins, organelles and lipids. In this study, the hypothesis that obesity could lead to impairment in hypothalamic autophagy in mice was evaluated by examining the hypothalamic distribution and
Dominica Ratuszny et al.
Human gene therapy, 26(10), 698-707 (2015-07-15)
Corneal scarring is an expected outcome of corneal injury or infection and is one of the major causes for visual loss. The formation of light-scattering myofibroblasts is thought to be the underlying cause of corneal haze formation. Recently, microRNA (miRNA)
Hiroki Kasama et al.
BMC cancer, 15, 563-563 (2015-08-01)
Adenosine A2b receptor (ADORA2B) encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. Little is known about the relevance of ADORA2B to
Yukio Nisimoto et al.
Biochemistry, 53(31), 5111-5120 (2014-07-26)
Nox4 is an oddity among members of the Nox family of NADPH oxidases [seven isoenzymes that generate reactive oxygen species (ROS) from molecular oxygen] in that it is constitutively active. All other Nox enzymes except for Nox4 require upstream activators
Kaja Urbańska et al.
Nanoscale research letters, 10, 98-98 (2015-04-09)
Recently, it has been shown that silver nanoparticles (AgNPs) provide a unique approach to the treatment of tumors, especially those of neuroepithelial origin. Thus, the aim of this study was to evaluate the impact of AgNPs on proliferation and activation
Ran Antes et al.
Current Alzheimer research, 12(4), 323-334 (2015-03-31)
Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is associated with neuronal and vascular impairments. Recent findings suggest that retina of apoE4 mice have synaptic and functional impairments. We presently investigated the effects of apoE4
Manabu Seino et al.
Oncology reports, 35(1), 593-601 (2015-11-05)
Ovarian cancer is the most lethal gynecological malignancy, for which platinum- and taxane-based chemotherapy plays a major role. Chemoresistance of ovarian cancer poses a major obstacle to the successful management of this devastating disease; however, effective measures to overcome platinum
Jianwei Xu et al.
Oncotarget, 5(16), 6983-6993 (2014-08-26)
Chemoresistance is one of the causes of poor prognosis in pancreatic cancer patients. However, the mechanisms of resistance remain unclear. Here we screened miRNAs associated with drug resistance in pancreatic cancer, and identified a panel of miRNAs dysregulated in gemcitabine-resistance
Qiao Zhang et al.
Journal of ethnopharmacology, 169, 99-108 (2015-04-22)
Fructus Alpiniae oxyphyllae (A. oxyphylla) is a traditional herb which is widely used in East Asian for the treatment of dyspepsia, diarrhea, abdominal pain, poor memory, inflammatory conditions and cancer. The cytotoxic activities of ethanol extract (EE) and five extract
Jing-Wei Li et al.
Molecular medicine reports, 12(5), 6903-6910 (2015-09-24)
MicroRNAs (miRs) regulate a number of physiological and pathological processes, including myocardial chronic hypoxia. Previous studies revealed that the expression of miR-146b is increased in vitro and in vivo following the induction of hypoxia. In the present study, the role
Ying Dong et al.
Cancer letters, 361(1), 137-146 (2015-03-05)
Dasatinib-based therapy is often used as a second-line therapeutic strategy for imatinib-resistance gastrointestinal stromal tumors (GISTs); however, acquired aberrant activation of dasatinib target proteins, such as c-KIT and PDGFRβ, attenuates the therapeutic efficiency of dasatinib. Combination therapy which inhibits the
Annett Richter et al.
Planta, 241(6), 1351-1361 (2015-02-15)
Of the three functional FPPS identified in maize, fpps3 is induced by herbivory to produce FDP important for the formation of the volatile sesquiterpenes of plant defense. Sesquiterpenes are not only crucial for the growth and development of a plant
Jia-yuan Wu et al.
Acta pharmacologica Sinica, 36(9), 1043-1052 (2015-08-25)
In the penumbra after focal cerebral ischemia, an increase of protease Omi is linked to a decrease of Hs1-associated protein X-1 (Hax-1), a protein belonging to the Bcl-2 family. In this study we investigated the mechanisms underlying the regulation of
Jin-Yuan Fan et al.
Molecular and cellular biology, 35(14), 2414-2424 (2015-05-06)
Drosophila DBT and vertebrate CKIε/δ phosphorylate the period protein (PER) to produce circadian rhythms. While the C termini of these orthologs are not conserved in amino acid sequence, they inhibit activity and become autophosphorylated in the fly and vertebrate kinases.
Stefan Sulmann et al.
Scientific reports, 5, 11228-11228 (2015-06-11)
Zebrafish photoreceptor cells express six guanylate cyclase-activating proteins (zGCAPs) that share a high degree of amino acid sequence homology, but differ in Ca(2+)-binding properties, Ca(2+)-sensitive target regulation and spatial-temporal expression profiles. We here study a general problem in cellular Ca(2+)-sensing
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