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Stephen E McGowan et al.
American journal of physiology. Lung cellular and molecular physiology, 307(8), L618-L631 (2014-08-26)
Signaling through platelet-derived growth factor receptor-α (PDGFRα) is required for alveolar septation and participates in alveolar regeneration after pneumonectomy. In both adipose tissue and skeletal muscle, bipotent pdgfrα-expressing progenitors expressing delta-like ligand-1 or sex-determining region Y box 9 (Sox9) may
Lei Sui et al.
International journal of pharmaceutics, 471(1-2), 157-165 (2014-05-24)
The efficacy of carbon nanotubes based drug delivery systems (DDSs) has long been compromised by low drug loading efficiency and rapid release profile, especially for drugs encapsulated inside nanotubes. To address these deficiencies, the large-inner-diameter multi-walled carbon nanotubes (LID-MWCNTs) were
Christine Burkard et al.
PLoS pathogens, 10(11), e1004502-e1004502 (2014-11-07)
Enveloped viruses need to fuse with a host cell membrane in order to deliver their genome into the host cell. While some viruses fuse with the plasma membrane, many viruses are endocytosed prior to fusion. Specific cues in the endosomal
Giampiero Colombano et al.
ChemMedChem, 10(2), 380-395 (2014-10-24)
Inhibition of fatty acid amide hydrolase (FAAH) activity is under investigation as a valuable strategy for the treatment of several disorders, including pain and drug addiction. A number of potent FAAH inhibitors belonging to different chemical classes have been disclosed
M M-G Sun et al.
Osteoarthritis and cartilage, 22(7), 996-1006 (2014-05-24)
Activation of the Liver X Receptor (LXR) has recently been identified as a therapeutic strategy for osteoarthritis (OA). Human OA articular cartilage explants show decreased LXR expression, and LXRβ-null mice display OA-like symptoms. LXR agonist administration to OA articular cartilage
Sang Mi Han et al.
BMC complementary and alternative medicine, 14, 286-286 (2014-08-06)
Free radicals are involved in neuronal cell death in human neurodegenerative diseases. Since ancient times, honeybee venom has been used in a complementary medicine to treat various diseases and neurologic disorders. Melittin, the main component of honeybee venom, has various
François Vromman et al.
PloS one, 9(6), e99197-e99197 (2014-06-10)
Chlamydiae are obligate intracellular bacteria. These pathogens develop inside host cells through a biphasic cycle alternating between two morphologically distinct forms, the infectious elementary body and the replicative reticulate body. Recently, C. trachomatis strains stably expressing fluorescent proteins were obtained.
Yong Lu et al.
Nature communications, 5, 4229-4229 (2014-06-25)
Dendritic cell (DC)-based cancer immunotherapy is a promising method, but so far has demonstrated limited clinical benefits. Regulatory T cells (Tregs) represent a major obstacle to cancer immunotherapy approaches. Here we show that inhibiting p38 MAPK during DC differentiation enables
R Imbert et al.
Human reproduction (Oxford, England), 29(9), 1931-1940 (2014-06-25)
Do the benefits of ovarian tissue cryopreservation outweigh the risks for patients seeking to preserve fertility before gonadotoxic treatment in various indications? In >90% of the patients undergoing cryopreservation of ovarian tissue, oncological treatment was associated with a reduced ovarian
Xinmei Wang et al.
Biochimica et biophysica acta, 1853(1), 244-253 (2014-12-03)
A major obstacle to successful treatment of hepatocellular carcinoma (HCC) is its high resistance to cytotoxic chemotherapy due to overexpression of multidrug resistance genes. Activation of the AKT pathway is known to be involved in chemoresistance in HCC; however, the
Hercules Antônio da Silva-Souza et al.
Biochimica et biophysica acta, 1838(7), 1967-1977 (2014-04-20)
We have previously described that arachidonic acid (AA)-5-lipoxygenase (5-LO) metabolism inhibitors such as NDGA and MK886, inhibit cell death by apoptosis, but not by necrosis, induced by extracellular ATP (ATPe) binding to P2X7 receptors in macrophages. ATPe binding to P2X7
Sudipto Bari et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(7), 1643-1656 (2015-06-28)
In this study, we report that surface functional groups of single walled carbon nanotubes (f-SWCNT) are critical for mediating survival and ex vivo expansion of hematopoietic stem and progenitor cells (HSPC) in human umbilical cord blood (UCB). In comparison to
Arnatchai Maiuthed et al.
Anticancer research, 34(12), 7111-7117 (2014-12-17)
Resistance to chemotherapeutic agents, as well as enhanced metastasis, have been frequently reported in lung cancer. Cytotoxicity and proliferative effects of cisplatin on H460 lung cancer cells were evaluated by the MTT assay. Migration capacity was evaluated by the wound
Avery Sonnenberg et al.
Electrophoresis, 35(12-13), 1828-1836 (2014-04-12)
Conventional methods for the isolation of cancer-related circulating cell-free (ccf) DNA from patient blood (plasma) are time consuming and laborious. A DEP approach utilizing a microarray device now allows rapid isolation of ccf-DNA directly from a small volume of unprocessed
Gwenaëlle Sana et al.
Cell transplantation, 23(9), 1127-1142 (2013-04-16)
The success of liver cell therapy remains closely dependent on how well the infused cells can be accepted after transplantation and is directly related to their degree of immunogenicity. In this study, we investigated the in vitro immunogenic properties of
A Zywert et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65(3), 425-433 (2014-06-17)
Cyclic adenosine monophosphate (cAMP) plays important role in the potentiation of insulin secretion in pancreatic B-cells. However, the relevance of cAMP-degrading enzymes in the regulation of insulin secretion is not fully elucidated. The present work was undertaken to determine effects
Alexander P Harding et al.
Regulatory toxicology and pharmacology : RTP, 71(2), 244-250 (2014-12-30)
Of all the in vitro mutagenicity assays, the Ames test displays the best correlation with rodent carcinogenicity and therefore carries significant weight with the food and drug regulatory bodies. Aromatic amines (AA) are ubiquitous structural groups in food and drug
Jevgenija Ponomarenko et al.
Phytochemistry, 103, 178-187 (2014-04-08)
A series of diarylheptanoids, namely 1,7-bis-(3,4-dihydroxyphenyl)-heptan-3-one-5-O-D-xylopyranoside (oregonin), 1,7-bis-(3,4-dihydroxyphenyl)-3-hydroxyheptane-5-O-β-D-xylopyranoside and 1,7-bis-(4-hydroxyphenyl)-heptane-3-one-5-O-β-D-glucopyranoside (platyphylloside), were isolated from the bark of alder family trees, a species widely spread over in Europe. As antioxidants, these natural polyphenols have a promising potential in various fields of
Jingjing Wu et al.
International journal of oncology, 45(1), 95-103 (2014-05-09)
Curcumin, one of the main bioactive components extracted from a traditional Chinese medicinal herb, exhibits potent anticancer activity against many types of cancer cells including nasopharyngeal carcinoma (NPC). However, the detailed molecular mechanism underlying this is not clearly understood. In
Shalmali Avinash Pradhan et al.
Nucleic acids research, 42(10), 6243-6255 (2014-04-22)
The TSC2 gene, mutated in patients with tuberous sclerosis complex (TSC), encodes a 200 kDa protein TSC2 (tuberin). The importance of TSC2 in the regulation of cell growth and proliferation is irrefutable. TSC2 in complex with TSC1 negatively regulates the
Osama A Alsaied et al.
Surgery, 156(2), 270-279 (2014-06-24)
Sorafenib is the only drug approved by the Food and Drug Administration for metastatic hepatocellular carcinoma (HCC). Triptolide, a diterpene triepoxide, exhibits antineoplastic properties in multiple tumor cell types. In this study, we examined the effects of these agents and
Silvana Pasetto et al.
PloS one, 9(12), e115323-e115323 (2014-12-30)
HIV infection by sexual transmission remains an enormous global health concern. More than 1 million new infections among women occur annually. Microbicides represent a promising prevention strategy that women can easily control. Among emerging therapies, natural small molecules such as
Y Chen et al.
Transplantation proceedings, 46(5), 1649-1657 (2014-06-18)
The efficacy of any bioartificial liver device requires both rapid production and proper bioactivity of the cells for the bioreactor. The goal of this study was to observe the effect of spinner speed and cell density on the proliferation of
Baihe Chen et al.
British journal of pharmacology, 171(15), 3741-3753 (2014-04-23)
Cardiac rupture is a catastrophic complication that occurs after acute myocardial infarction (MI) and, at present, there are no effective pharmacological strategies for preventing this condition. Here we investigated the effect of the angiotensin II receptor blocker olmesartan (Olm) on
Ahmed El Marghani et al.
The Science of the total environment, 488-489, 228-235 (2014-05-20)
The increasing contamination of freshwater with pharmaceuticals, surfactants, pesticides and other organic compounds are of major concern. As these contaminants are detected at trace levels in the environment it is important to determine if they elicit biological responses at the
Maike Buchner et al.
Nature communications, 6, 6471-6471 (2015-03-11)
Despite recent advances in the cure rate of acute lymphoblastic leukaemia (ALL), the prognosis for patients with relapsed ALL remains poor. Here we identify FOXM1 as a candidate responsible for an aggressive clinical course. We show that FOXM1 levels peak
Tiago Rafael Veloso et al.
The Journal of infectious diseases, 211(1), 72-79 (2014-08-03)
Infective endocarditis (IE) mostly occurs after spontaneous low-grade bacteremia. Thus, IE cannot be prevented by circumstantial antibiotic prophylaxis. Platelet activation following bacterial-fibrinogen interaction or thrombin-mediated fibrinogen-fibrin polymerization is a critical step in vegetation formation. We tested the efficacy of antiplatelet
Giuseppe Di Giovanni et al.
CNS neuroscience & therapeutics, 20(7), 633-640 (2014-05-23)
A considerable body of human and animal experimental evidence links monoaminergic systems and cognition. Monoamine oxidase inhibitors (MAOIs), being able to enhance monoaminergic transmission and having neuroprotective properties, might represent a promising therapeutic strategy in cognitive impairment in Alzheimer's disease
Chunlei Wang et al.
European journal of medical research, 19, 49-49 (2014-09-27)
Among glioma treatment strategies, arsenic trioxide (As2O3) has shown efficacy as a therapeutic agent against human gliomas. However, the exact antitumor mechanism of action of As2O3 is still unclear. Mitochondria are considered to be the major source of intracellular reactive
Nima Sepehri et al.
International journal of pharmaceutics, 471(1-2), 485-497 (2014-06-01)
SN38 (7-ethyl-10-hydroxyl camptothecin), a potent metabolite of irinotecan, has been considered as an anticancer candidate. Its clinical development has been hampered due to its poor solubility. As a result, SN38 loaded poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) was developed in
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