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Sachiko Murase
International journal of molecular sciences, 16(7), 15659-15669 (2015-07-18)
Excitatory/inhibitory imbalances are implicated in many neurological disorders. Previously, we showed that chronically elevated network activity induces vulnerability in neurons due to loss of signal transducer and activator of transcription 3 (STAT3) signaling in response to the impairment of the
Ryan Moazamian et al.
Molecular human reproduction, 21(6), 502-515 (2015-04-04)
Oxidative stress is known to compromise human sperm function and to activate the intrinsic apoptotic cascade in these cells. One of the key features of oxidatively stressed spermatozoa is the induction of a lipid peroxidation process that results in the
Roberto De Pascalis et al.
PloS one, 10(5), e0126570-e0126570 (2015-05-15)
In the last decade several new vaccines against Francisella tularensis, which causes tularemia, have been characterized in animal models. Whereas many of these vaccine candidates showed promise, it remains critical to bridge the preclinical studies to human subjects, ideally by
Jennifer A Boylston et al.
Cell cycle (Georgetown, Tex.), 13(18), 2913-2930 (2014-12-09)
Fragile histidine triad (FHIT) gene deletions are among the earliest and most frequent events in carcinogenesis, particularly in carcinogen-exposed tissues. Though FHIT has been established as an authentic tumor suppressor, the mechanism underlying tumor suppression remains opaque. Most experiments designed
David Westover et al.
Molecular cancer, 14, 92-92 (2015-05-01)
Irinotecan is a camptothecin analogue currently used in clinical practice to treat advanced colorectal cancer. However, acquired resistance mediated by the drug efflux pump ABCG2 is a recognized problem. We reported on a novel camptothecin analogue, FL118, which shows anticancer
Lei Yang et al.
Molecular biology reports, 42(5), 927-935 (2014-11-26)
MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of gene expression. MiR-1908 is a recently identified miRNA that is highly expressed in human adipocytes. However, it is not known what role of miR-1908 is involved in the regulation
Cristina N Butterfield et al.
Biochimica et biophysica acta, 1854(12), 1853-1859 (2015-09-04)
Multicopper oxidases (MCOs) catalyze the oxidation of a diverse group of metal ions and organic substrates by successive single-electron transfers to O2 via four bound Cu ions. MnxG, which catalyzes MnO2 mineralization by oxidizing both Mn(II) and Mn(III), is unique
Xinmin Zhao et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(9), 6733-6740 (2015-04-03)
Lung cancer is the leading cause of cancer-related death in the world. Previous report has identified ribosomal protein s15a (RPS15A) as a TGF-β-responsible gene in the lung adenocarcinoma cell line A549. In this study, we used specific si-RNA to downregulate
Caixia Liu et al.
Toxicon : official journal of the International Society on Toxinology, 106, 46-56 (2015-09-20)
Aflatoxin B1 (AFB1) is a well-known human hepatotoxicant and genotoxicant. Recent studies demonstrated that aberrant miRNA expression patterns were correlated with the cellular and genetic lesions induced by chemicals. To explore the role of miRNAs in AFB1-induced hepatotoxicity and genotoxicity
Izabela Waclawska et al.
Biological chemistry, 396(9-10), 1117-1126 (2015-07-07)
The trimeric transporter BetP counteracts hyperosmotic stress by a fast increase in transport rate in order to accumulate the compatible solute betaine. The positively charged α-helical C-terminal domain acts as an osmosensor perceiving the increase in the internal potassium (K+)
Sunwoo Koo et al.
Anticancer research, 35(6), 3209-3215 (2015-05-31)
Novel treatment strategies aiming to eliminate or attenuate the invasive phenotype of glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, could offer a profound therapeutic benefit to patients. We previously demonstrated one method to create invasive sub-populations
Saleh Al-Quraishy et al.
The journal of venomous animals and toxins including tropical diseases, 20(1), 42-42 (2014-09-27)
Snake venoms are synthesized and stored in venom glands. Most venoms are complex mixtures of several proteins, peptides, enzymes, toxins and non-protein components. In the present study, we investigated the oxidative stress and apoptosis in rat liver cells provoked by
Upeksha P Chandrasiri et al.
Malaria journal, 14, 193-193 (2015-05-11)
Malaria and undernutrition frequently coexist, especially in pregnant women and young children. Nutrient supplementation of these vulnerable groups might reduce their susceptibility to malaria by improving immunity. Antibody immunity to antigens expressed by a placental-binding parasite isolate, a non-placental binding
Mariana Macedo de Almeida et al.
Journal of oleo science, 64(5), 539-551 (2015-04-07)
Synthetic supplements of conjugated linoleic acid (CLA) containing 50:50 mixture of cis-9, trans-11 and trans-10, cis-12 CLA isomers have been commercialized in some places for reducing body fat. However the safety of this CLA mixture is controversial and in some
M Cheema et al.
Journal of dairy science, 98(8), 5155-5163 (2015-06-16)
The agreed biological function of the casein micelles in milk is to carry minerals (calcium, magnesium, and phosphorus) from mother to young along with amino acids for growth and development. Recently, native and modified casein micelles were used as encapsulating
Natalia A Nikitenko et al.
Biochimie, 113, 10-16 (2015-03-23)
Human adenoviruses are non-enveloped DNA viruses causing various infections; their pathogenicity varies dependent on virus species and type. Although acute infections can sometimes take severe courses, they are rarely fatal in immune-competent individuals. Adenoviral conjunctivitis and epidemic keratoconjunctivitis are hyperacute
Hung-Te Hsu et al.
Inflammation, 38(1), 415-423 (2014-10-25)
Propofol is a widely used intravenous anesthetic. The aim of this study was to investigate the roles of nuclear factor erythroid-2-related factor 2 (Nrf2) and NADPH oxidase (NOX) in propofol protection in inflammatory conditions induced by lipopolysaccharide (LPS). Human alveolar
Alex I Chernyavsky et al.
BMC cancer, 15, 152-152 (2015-04-18)
One of the major controversies of contemporary medicine is created by an increased consumption of nicotine and growing evidence of its connection to cancer, which urges elucidation of the molecular mechanisms of oncogenic effects of inhaled nicotine. Current research indicates
Haiyan Wu et al.
Langmuir : the ACS journal of surfaces and colloids, 31(31), 8566-8576 (2015-07-15)
Dielectric behaviors of spherical polyelectrolyte brush (SPB) suspensions under various mass fractions of SPB and the pH of solution were investigated in a frequency range of 40 Hz to 110 MHz. The SPB consists of a polystyrene (PS) core grafted
Chao Liu et al.
International journal of molecular medicine, 36(4), 1081-1087 (2015-08-05)
The main pathogenic events in osteoarthritis (OA) include loss and abnormal remodeling of cartilage extracellular matrix. The present study aimed to evaluate the protective effect of tauroursodeoxycholic acid on chondrocyte apoptosis induced by endoplasmic reticulum (ER) stress. Articular cartilage tissues
Lingying Zhong et al.
Biological trace element research, 164(1), 130-138 (2014-12-17)
Literature to date has confirmed that cadmium (Cd) can accomplish its toxic effects via the free radical-induced damage, but Cd itself cannot generate free radicals directly. Nitric oxide (NO) is a fundamental molecule that interplays with reactive oxygen species (ROS)
Cheng-Yao Lin et al.
World journal of gastroenterology, 21(7), 2047-2057 (2015-02-27)
To investigate the possible mechanism of how glucose promotes invasion and metastasis of colon cancer cells. CT-26 rat colorectal cancer cells were cultured in different concentrations of glucose environments (10, 20, and 30 mmol/L). Wound healing assay and transwell chamber
Christy Rosaline Nirmal et al.
European journal of medicinal chemistry, 105, 182-193 (2015-10-23)
Tuberculosis, caused by Mycobacterium tuberculosis, remains a serious global health threat, highlighting the urgent need for novel antituberculosis drugs. The shikimate pathway, responsible for aromatic amino acid biosynthesis, is required for the growth of Mycobacterium tuberculosis and is a potential
Alessandra Gianoncelli et al.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 29(4), 285-300 (2015-09-04)
Authorization to market a biosimilar product by the appropriate institutions is expected based on biosimilarity with its originator product. The analogy between the originator and its biosimilar(s) is assessed through safety, purity, and potency analyses. In this study, we proposed
Gyuman Park et al.
Biomaterials, 54, 201-212 (2015-04-25)
The possibility of controlling cell fates by overexpressing specific transcription factors has led to numerous studies in stem cell research. Small molecules can be used, instead of transcription factors, to induce the de-differentiation of somatic cells or to induce pluripotent
Feng-Yu Gao et al.
Molecular medicine reports, 12(5), 7005-7010 (2015-09-02)
Gastric cancer is one of the most frequent malignancies and a leading cause of cancer-related mortality worldwide. MicroRNAs (miRs), a class of small non‑coding RNAs, have been shown to be critical in tumorigenesis. In the present study, the expression levels
Srikant Rangaraju et al.
Journal of Alzheimer's disease : JAD, 44(3), 797-808 (2014-11-02)
Recent genetic studies suggest a central role for innate immunity in Alzheimer's disease (AD) pathogenesis, wherein microglia orchestrate neuroinflammation. Kv1.3, a voltage-gated potassium channel of therapeutic relevance in autoimmunity, is upregulated by activated microglia and mediates amyloid-mediated microglial priming and
Jiao Xu et al.
Oncology reports, 33(5), 2227-2234 (2015-03-05)
The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP-binding cassette (ABC) transporter family, members of which are involved in various types of cancer. The relationship between CFTR and ovarian cancer remains to be elucidated. The aim of the
Ik-Rak Jung et al.
Molecular and cellular endocrinology, 407, 74-84 (2015-03-18)
High levels of plasma free fatty acid are thought to contribute to the loss of pancreatic beta-cells in type 2 diabetes. In particular, saturated fatty acid such as palmitate or stearate can induce apoptosis in cultured beta cells (lipotoxicity). Endoplasmic
Katrien Smolders et al.
Scientific reports, 5, 10917-10917 (2015-06-06)
Advancing the quest for new drug targets demands the development of innovative plasma membrane proteome research strategies applicable to small, functionally defined tissue samples. Biotinylation of acute tissue slices and streptavidin pull-down followed by shotgun proteomics allowed the selective extraction
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