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720143
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Chen-Ting Lee et al.
PloS one, 10(3), e0120327-e0120327 (2015-03-21)
Traditional treatments, including a variety of thermal therapies have been known since ancient times to provide relief from rheumatoid arthritis (RA) symptoms. However, a general absence of information on how heating affects molecular or immunological targets relevant to RA has
Dong Liang et al.
Endocrine journal, 62(10), 907-920 (2015-07-28)
Type 2 diabetes mellitus (T2D) is a chronic metabolic disorder resulting from defects in both insulin secretion and insulin activity. The deficit and dysfunction of insulin secreting β-cells are signature symptoms of T2D. Additionally, in pancreatic β-cells, a small group
Milan Jana et al.
Nanotechnology, 26(7), 075402-075402 (2015-02-03)
Co9S8/reduced graphene oxide (RGO) composites were prepared on nickel foam substrate through hydrothermal reaction and used directly as supercapacitor electrode. The field emission scanning electron microscopy analysis of the composites showed the formation of Co9S8 nano-rods on the RGO surfaces.
Matthew C Henn et al.
Journal of the American Heart Association, 4(8), e002016-e002016 (2015-08-26)
ATP-sensitive potassium (K(ATP)) channel openers provide cardioprotection in multiple models. Ion flux at an unidentified mitochondrial K(ATP) channel has been proposed as the mechanism. The renal outer medullary kidney potassium channel subunit, potassium inward rectifying (Kir)1.1, has been implicated as
Nani Maharani et al.
Circulation journal : official journal of the Japanese Circulation Society, 79(12), 2659-2668 (2015-10-20)
Hyperuricemia induces endothelial dysfunction, oxidative stress and inflammation, increasing cardiovascular morbidities. It also raises the incidence of atrial fibrillation; however, underlying mechanisms are unknown. The effects of urate on expression of Kv1.5 in cultured mouse atrial myocytes (HL-1 cells) using
Zaiwen Fan et al.
Clinical and experimental hypertension (New York, N.Y. : 1993), 37(5), 381-387 (2015-04-10)
To test the hypothesis that chronic hypoxic pulmonary hypertension (CH-PH) is associated with increased survivin and decreased voltage-gated potassium (KV) channels expression in pulmonary arteries, rats were randomized as: normoxia (N); normoxia + YM155, survivin suppressor (NY); hypoxia (H); hypoxia + YM155 (HY). HY
Olli H Tuovinen et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 50(10), 718-726 (2015-08-15)
The purpose of this study was to assess atrazine mineralization in surface and subsurface samples retrieved from vertical cores of agricultural soils from two farm sites in Ohio. The Defiance site (NW-Ohio) was on soybean-corn rotation and Piketon (S-Ohio) was
Tenna Jørgensen et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(6), 943-950 (2015-03-12)
It is well known that few weeks of high fat (HF) diet may induce metabolic disturbances and mitochondrial dysfunction in skeletal muscle. However, little is known about the effects of long-term HF exposure and effects on brain mitochondria are unknown.
Yanhong Li et al.
PloS one, 10(3), e0121884-e0121884 (2015-03-27)
Nosema bombycis, the first identified microsporidium, is a destructive pathogen of the silkworm Bombyx mori and causes severe worldwide economic losses in sericulture. Major microsporidian structural proteins, such as the spore wall protein (SWP), are known to be involved in
Qian Ran et al.
Scientific reports, 5, 16209-16209 (2015-11-06)
Fe3O4 magnetic nanoparticles (Fe3O4-MNPs) have been widely used in clinical diagnosis. Hemocompatibility of the nanoparticles is usually evaluated by hemolysis. However, hemolysis assessment does not measure the dysfunctional erythrocytes with pathological changes on the unbroken cellular membrane. The aim of
Umberto M Musazzi et al.
International journal of pharmaceutics, 489(1-2), 177-185 (2015-05-03)
Recent studies demonstrated that post-herpetical and inflammatory pain can be locally managed by morphine gels, empirically chosen. Aiming to rationalize the selection of the most suitable opioid for the cutaneous delivery, we studied the in vitro penetration through human epidermis
Leonor C Costa et al.
Environmental science and pollution research international, 22(23), 18574-18589 (2015-09-24)
This study aimed to assess the mechanisms of innate immune function responses to silica-coated iron oxide nanoparticle functionalized with dithiocarbamate groups (IONP) exposure alone and its associated mercury (Hg) in European eel (Anguilla anguilla L.) phagocytes isolated from peritoneum (P-phagocytes)
Masayuki Sugimoto et al.
Biochimica et biophysica acta, 1851(12), 1554-1565 (2015-09-24)
Sphingomyelin (SM) is synthesized by SM synthase (SMS) from ceramide (Cer). SM regulates signaling pathways and maintains organ structure. SM comprises a sphingoid base and differing lengths of acyl-chains, but the importance of its various forms and regulatory synthases is
Serkan Koldaş et al.
Journal of the science of food and agriculture, 95(4), 786-798 (2014-09-10)
A detailed phytochemical analysis of Origanum vulgare L. ssp. viride (Boiss.) Hayek was carried out and the antioxidant activities of five different crude extracts were determined. The antiproliferative activities of the extracts were determined using the xCELLigence system (Real Time
Gas phase base-catalyzed dehydrogenations of cyclic hydrocarbons over a KOH/Al2O3 catalyst
Neumann R and Sasson Y
J. Mol. Catal., 35(1), 131-136 (1986)
K M Bekers et al.
Yeast (Chichester, England), 32(8), 541-557 (2015-06-11)
With the current quantitative metabolomics techniques, only whole-cell concentrations of NAD and NADH can be quantified. These measurements cannot provide information on the in vivo redox state of the cells, which is determined by the ratio of the free forms
Shashwati U Atwe et al.
Journal of controlled release : official journal of the Controlled Release Society, 194, 45-52 (2014-08-26)
Oral vaccination can offer a painless and convenient method of vaccination. Furthermore, in addition to systemic immunity it has potential to stimulate mucosal immunity through antigen-processing by the gut-associated lymphoid tissues. In this study we propose the concept that pollen
Nicola Mosca et al.
Molecular biology reports, 42(8), 1333-1340 (2015-04-26)
Dicer is central to small RNA silencing pathways, thus playing an important role in physiological and pathological states. Recently, a number of mutations in dicer gene have been identified in diverse types of cancer, implicating Dicer in oncogenic cooperation. Here
Andrew R Chandna et al.
The European journal of neuroscience, 41(3), 341-351 (2014-11-29)
Autonomic dysfunction is a serious complication of diabetes and can lead to cardiovascular abnormalities and premature death. It was recently proposed that autonomic dysfunction is triggered by oxidation-mediated inactivation of neuronal nicotinic acetylcholine receptors (nAChRs), impairing synaptic transmission in sympathetic
A Mohammad et al.
Clinical toxicology (Philadelphia, Pa.), 53(2), 102-107 (2015-01-23)
Prussian blue, ferric hexacyanoferrate is approved for (oral) treatment of internal contamination with radioisotopes of cesium or thallium. Cyanide makes up 35-40% of Prussian blue's molecular composition; thus, cyanide may be released during transit through the digestive tract under physiological
Jochem Louisse et al.
Archives of toxicology, 89(7), 1135-1148 (2014-06-18)
The use of laboratory animals for toxicity testing in chemical safety assessment meets increasing ethical, economic and legislative constraints. The development, validation and application of reliable alternatives for in vivo toxicity testing are therefore urgently needed. In order to use
Chong-hao Bi et al.
Bioresource technology, 185, 185-193 (2015-03-17)
A novel process was developed for converting scum, a waste material from wastewater treatment facilities, to biodiesel. Scum is an oily waste that was skimmed from the surface of primary and secondary settling tanks in wastewater treatment plants. Currently scum
Daniel S Levic et al.
Journal of molecular medicine (Berlin, Germany), 93(2), 165-176 (2015-01-07)
Anderson disease (ANDD) or chylomicron retention disease (CMRD) is a rare, hereditary lipid malabsorption syndrome associated with mutations in the SAR1B gene that is characterized by failure to thrive and hypocholesterolemia. Although the SAR1B structure has been resolved and its
José L Martínez et al.
Biotechnology and bioengineering, 112(1), 181-188 (2014-08-02)
Efficient production of appropriate oxygen carriers for transfusions (blood substitutes or artificial blood) has been pursued for many decades, and to date several strategies have been used, from synthetic polymers to cell-free hemoglobin carriers. The recent advances in the field
Jing Feng et al.
The Journal of biological chemistry, 290(25), 15487-15495 (2015-05-07)
Among the three extracellular domains of the tetrameric voltage-gated K(+) (Kv) channels consisting of six membrane-spanning helical segments named S1-S6, the functional role of the S1-S2 linker still remains unclear because of the lack of a peptide ligand. In this
Frank Lippert et al.
Caries research, 49(5), 467-476 (2015-08-01)
The aims of this laboratory study were to compare the effects of lesion baseline severity, mineral distribution and substrate on remineralization and progression of caries lesions created in root dentin. Lesions were formed in dentin specimens prepared from human and
Anja Balk et al.
Pharmaceutical research, 32(6), 2154-2167 (2014-12-24)
A poorly water soluble acidic active pharmaceutical ingredient (API) was transformed into an ionic liquid (IL) aiming at faster and higher oral availability in comparison to a prodrug. API preparations were characterized in solid state by single crystal and powder
Danny C LeBert et al.
Development (Cambridge, England), 142(12), 2136-2146 (2015-05-28)
Acute and chronic injuries are characterized by leukocyte infiltration into tissues. Although matrix metalloproteinase 9 (Mmp9) has been implicated in both conditions, its role in wound repair remains unclear. We previously reported a zebrafish chronic inflammation mutant caused by an
Sung-Ah Lim et al.
Journal of alternative and complementary medicine (New York, N.Y.), 21(9), 530-538 (2015-07-17)
The aim of the present study is to highlight the beneficial effects of yoga practice on bio-parameters, such as oxidative stress, antioxidant components, immune functions, and secretion of stress hormones, in healthy young people. This study was conducted on healthy
Vid V Flis et al.
PloS one, 10(8), e0135084-e0135084 (2015-08-05)
In the yeast Saccharomyces cerevisiae, phosphatidylcholine (PC), the major phospholipid (PL) of all organelle membranes, is synthesized via two different pathways. Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through
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