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I Gkouveris et al.
Pathology oncology research : POR, 26(1), 183-192 (2018-03-23)
p38 protein belongs to Mitogen-activated protein kinases family that link extracellular stimuli with intracellular responses participating in numerous of fundamental cell processes. Persistent activation of STAT3 has been associated with cell proliferation, differentiation and apoptosis in oral squamous cell carcinoma...
Emma Gunderson et al.
microPublication biology, 2020 (2020-07-25)
Wassamon Boonying et al.
Journal of neurochemistry, 150(3), 312-329 (2019-02-09)
Loss of function mutations in the PTEN-induced putative kinase 1 (Pink1) gene have been linked with an autosomal recessive familial form of early onset Parkinson's disease (PD). However, the underlying mechanism(s) responsible for degeneration remains elusive. Presently, using co-immunoprecipitation in...
Philip Kitchen et al.
Cancer research, 80(4), 757-770 (2019-12-18)
Aberrant Notch and Wnt signaling are known drivers of cholangiocarcinoma (CCA), but the underlying factors that initiate and maintain these pathways are not known. Here, we show that the proline-rich homeodomain protein/hematopoietically expressed homeobox (PRH/HHEX) transcription factor forms a positive...
A Islam et al.
European cells & materials, 37, 153-174 (2019-02-21)
Mesenchymal stromal cells (MSCs), given their regenerative potential, are being investigated as a potential therapeutic tool for cartilage lesions. MSCs express several bioactive molecules which act in a paracrine fashion to modulate the tissue microenvironment. Yet, little is known about...
Kholoud K Khoja et al.
Nutrients, 12(4) (2020-04-16)
Iron deficiency is a global epidemic affecting a third of the world's population. Current efforts are focused on investigating sustainable ways to improve the bioavailability of iron in plant-based diets. Incorporating microgreens into the diet of at-risk groups in populations...
Kenya Yamase et al.
PloS one, 14(8), e0220917-e0220917 (2019-08-09)
As a result of a high-throughput in situ hybridization screening for adult mouse testes, we found that the mRNA for Tmco5 is expressed in round and elongating spermatids. Tmco5 belongs to the Tmco (Transmembrane and coiled-coil domains) gene family and...
Makoto Hosoya et al.
Regenerative therapy, 10, 54-63 (2018-12-26)
Pendred syndrome is an autosomal-recessive disease characterized by congenital hearing loss and thyroid goiter. Previously, cell stress susceptibilities were shown to increase in patient-derived cells with intracellular aggregation using an in vitro acute cochlear cell model derived from patient-specific pluripotent stem...
Takumi Nakamura et al.
Scientific reports, 8(1), 16025-16025 (2018-10-31)
Various molecular biology techniques implementing genome editing have made it possible to generate mouse mutants for nearly all known genes; as a result, the International Mouse Phenotyping Consortium (IMPC) database listing the phenotypes of genetically modified mice has been established....
Kazuki Hattori et al.
PloS one, 15(10), e0232645-e0232645 (2020-10-28)
Boosting energy expenditure by harnessing the activity of brown adipocytes is a promising strategy for combatting the global epidemic of obesity. Many studies have revealed that the β3-adrenergic receptor agonist is a potent activator of brown adipocytes, even in humans...
Ali Samadikuchaksaraei et al.
Methods in molecular biology (Clifton, N.J.), 330, 233-248 (2006-07-19)
We present a protocol that has been developed for induction of the differentiation of murine embryonic stem (ES) cells to alveolar type II cells. With this protocol, undifferentiated murine ES cells are induced to form embryoid bodies (EBs). The 10-d-old...
Felix Wäldchen et al.
Nature communications, 11(1), 887-887 (2020-02-16)
The molecular organization of receptors in the plasma membrane of cells is paramount for their functionality. We combined lattice light-sheet (LLS) microscopy with three-dimensional (3D) single-molecule localization microscopy (dSTORM) and single-particle tracking to quantify the expression and distribution, and mobility...
Yuichiro Saito et al.
Journal of cell science, 133(12) (2020-05-22)
RIF1 controls both DNA replication timing and the DNA double-strand break (DSB) repair pathway to maintain genome integrity. However, it remains unclear how RIF1 links these two processes following exposure to ionizing radiation (IR). Here, we show that inhibition of...
Saturnin Ombinda-Lemboumba et al.
Journal of biophotonics, 12(7), e201800349-e201800349 (2019-02-28)
Transmission measurement has been perceived as a potential candidate for label-free investigation of biological material. It is a real-time, label-free and non-invasive optical detection technique that has found wide applications in pharmaceutical industry as well as the biological and medical...
Sonam Dhamija et al.
Nature cell biology, 22(8), 999-1010 (2020-07-29)
Nonstop or stop-loss mutations convert a stop into a sense codon, resulting in translation into the 3' untranslated region as a nonstop extension mutation to the next in-frame stop codon or as a readthrough mutation into the poly-A tail. Nonstop...
Mario Rothbauer et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 237, 118388-118388 (2020-05-04)
Glucose transport is key for cellular metabolism as well as physiological function and is maintained via passive facilitated and active sodium-glucose linked transport routes. Here, we present for the first time Fourier-transform infrared spectroscopy as a novel approach for quantification...
Masahiro Miura et al.
Oncology letters, 19(4), 2657-2666 (2020-03-29)
Predicting the risk of hepatocellular carcinoma (HCC) recurrence before treatment is necessary for developing subsequent treatment policies. Several tumor markers found in blood, such as alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II), are presently used...
Ashraful Islam et al.
BMC musculoskeletal disorders, 20(1), 19-19 (2019-01-12)
Autologous chondrocyte implantation (ACI) has been used over the last two decades to treat focal cartilage lesions aiming to delay or prevent the onset of osteoarthritis; however, some patients do not respond adequately to the procedure. A number of biomarkers...
Rudzani Malabi et al.
Journal of biophotonics, 12(10), e201800424-e201800424 (2019-05-30)
The introduction of highly active antiretroviral therapy (HAART) has significantly increased life expectancy and improved management of the human immunodeficiency virus-1 (HIV-1) disease globally. This well-established treatment regime has shown to reduce viral capacity to undetectable limits when using traditional...
Eva Vavříková et al.
European journal of medicinal chemistry, 127, 263-274 (2017-01-10)
A series of antioxidants was designed and synthesized based on conjugation of the hepatoprotective flavonolignan silybin with l-ascorbic acid, trolox alcohol or tyrosol via a C
Sun-Hee Hwang et al.
Current biology : CB, 29(5), 790-802 (2019-02-26)
Polycystic kidney disease proteins, polycystin-1 and polycystin-2, localize to primary cilia. Polycystin knockouts have severe cystogenesis compared to ciliary disruption, whereas simultaneous ciliary loss suppresses excessive cyst growth. These data suggest the presence of a cystogenic activator that is inhibited...
Karen Verboom et al.
Nucleic acids research, 47(16), e93-e93 (2019-06-20)
Single cell RNA sequencing methods have been increasingly used to understand cellular heterogeneity. Nevertheless, most of these methods suffer from one or more limitations, such as focusing only on polyadenylated RNA, sequencing of only the 3' end of the transcript...
Mable Lam et al.
eLife, 9 (2020-01-07)
Disruption of protein folding in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR)-a signaling network that ultimately determines cell fate. Initially, UPR signaling aims at cytoprotection and restoration of ER homeostasis; that failing, it drives apoptotic cell death....
Gabriella Marucci et al.
Life sciences, 205, 155-163 (2018-05-16)
A3 adenosine receptor (A3AR) signalling activation seems to mediate anticancer effect, and it has been targeted for drug development. The identification of potent and selective A3AR agonists could be crucial for cancer drug development. In the present study was determined...
Samantha Kent et al.
Cell reports, 33(2), 108248-108248 (2020-10-15)
Compartmentalization by liquid-liquid phase separation is implicated in transcription. It remains unclear whether and how transcriptional condensates accelerate the search of transcriptional regulatory factors for their target sites. Furthermore, the molecular mechanisms by which regulatory factors nucleate on chromatin to...
Eishin Mitsui et al.
Scientific reports, 9(1), 9952-9952 (2019-07-11)
KDM5 family members (A, B, C and D) that demethylate H3K4me3 have been shown to be involved in human cancers. Here we performed screening for KDM5A inhibitors from chemical libraries using the AlphaScreen method and identified a battery of screening...
Hitomi Sasaki et al.
Journal of food science, 85(8), 2498-2505 (2020-07-08)
Miso, a fermented paste made from soybeans, is used traditionally for seasoning of food. It has been a protein and nitrogen source since ancient times in Japan because of its high nutritional value. Furthermore, it has important health functions such...
Yi Yan et al.
Journal of colloid and interface science, 508, 87-94 (2017-08-22)
Tissue and biomedical engineering fields are in constant mutation and in searching for innovative processing techniques capable to tailor the material properties. In this work, poly(l-lactic acid) (PLLA) and elastomeric poly(glycerol sebacate) (PGS) were dissolved in the same solvents and...
Kazuki Hattori et al.
EMBO reports, 18(11), 2067-2078 (2017-09-10)
A wide variety of cell death mechanisms, such as ferroptosis, have been proposed in mammalian cells, and the classification of cell death attracts global attention because each type of cell death has the potential to play causative roles in specific...
Wakako Furuyama et al.
PLoS neglected tropical diseases, 14(9), e0008602-e0008602 (2020-09-05)
Besides the common Fc receptor (FcR)-mediated mechanism of antibody-dependent enhancement (ADE), Ebola virus (EBOV) is known to utilize the complement component C1q for ADE of infection. This mechanism is FcR-independent and mediated by cross-linking of virus-antibody-C1q complexes to cell surface...
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