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e1385

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Madhu Chauhan et al.
Biology of reproduction, 92(2), 39-39 (2014-11-15)
Adrenomedullin2 (ADM2) is reported to facilitate embryo implantation and placental development. Therefore, the current study was undertaken to identify if ADM2 has a functional role in ovary to facilitate its reproductive actions. This study shows that the expression of ADM2
Rubén Alcázar et al.
PLoS genetics, 10(12), e1004848-e1004848 (2014-12-17)
Mechanisms underlying speciation in plants include detrimental (incompatible) genetic interactions between parental alleles that incur a fitness cost in hybrids. We reported on recessive hybrid incompatibility between an Arabidopsis thaliana strain from Poland, Landsberg erecta (Ler), and many Central Asian
Nicola Franchi et al.
Developmental and comparative immunology, 46(2), 430-438 (2014-06-01)
The complement system is a fundamental effector mechanism of the innate immunity in both vertebrates and invertebrates. The comprehension of its roots in the evolution is a useful step to understand how the main complement-related proteins had changed in order
Karthyayani Rajamani et al.
Cell transplantation, 24(3), 493-507 (2015-02-06)
As assuring cell quality is an essential parameter for the success of stem cell therapy, the impact of various senescence-inducing stress signals, and strategies to circumvent them, has been an important area of focus in stem cell research. The aim
Mari Spildrejorde et al.
Physiological genomics, 46(14), 512-522 (2014-05-16)
The relative function of the P2X7 receptor, an ATP-gated ion channel, varies between humans due to polymorphisms in the P2RX7 gene. This study aimed to assess the functional impact of P2X7 variation in a random sample of the canine population.
Yang-Lei Yi et al.
Research in microbiology, 166(2), 93-101 (2015-02-02)
Strain A2 with algicidal activity against Microcystis aeruginosa was isolated and identified with the genus Acinetobacter on the basis of phenotypic tests and 16S rRNA gene analysis. It was identified with the species Acinetobactor guillouiae by partial rpoB sequence analysis.
J Bhagat et al.
Environmental science and pollution research international, 22(14), 10758-10768 (2015-03-12)
In vivo and in vitro exposures were used to investigate the genotoxicity of mercuric chloride (HgCl2) to the marine snail, Planaxis sulcatus. The comet assay protocol was validated on gill cells exposed in vitro to hydrogen peroxide (H2O2, 0-50 μM).
Jianyun Zhou et al.
BioMed research international, 2014, 254686-254686 (2014-09-23)
Trauma associated with infection may directly trigger a neuroendocrine reaction in vivo while the hormone epinephrine is known to mediate immune responses to inflammation after injury. However, the role of epinephrine during the earliest stage of trauma still remains unclear.
Irshad Ahmad et al.
International journal of biological macromolecules, 79, 193-200 (2015-05-06)
A detailed investigation on the mode of action and binding mechanism of a potent anticancer drug, 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DCR) with calf thymus DNA (ctDNA) was carried out. UV-vis and fluorescence spectrophotometry suggested the formation of complex between DCR and ctDNA. The
Francesca Borrelli et al.
Carcinogenesis, 35(12), 2787-2797 (2014-10-02)
Cannabigerol (CBG) is a safe non-psychotropic Cannabis-derived cannabinoid (CB), which interacts with specific targets involved in carcinogenesis. Specifically, CBG potently blocks transient receptor potential (TRP) M8 (TRPM8), activates TRPA1, TRPV1 and TRPV2 channels, blocks 5-hydroxytryptamine receptor 1A (5-HT1A) receptors and
Huma Syed et al.
Molecular medicine reports, 12(5), 7649-7656 (2015-09-24)
Cyclooxygenase (COX) enzymes are expressed in the brain; however, their role in hippocampus-dependent and cortex-dependent cognitive functions remains to be fully elucidated. The aim of the present study was to comparatively investigate the effects of piroxicam, a selective COX-I inhibitor
Mamie Yu et al.
Nature, 520(7547), 307-311 (2015-04-17)
Cell line misidentification, contamination and poor annotation affect scientific reproducibility. Here we outline simple measures to detect or avoid cross-contamination, present a framework for cell line annotation linked to short tandem repeat and single nucleotide polymorphism profiles, and provide a
Feng Long et al.
Antimicrobial agents and chemotherapy, 52(9), 3052-3060 (2008-07-02)
Active efflux of antimicrobial agents is one of the most important adapted strategies that bacteria use to defend against antimicrobial factors that are present in their environment. The NorM protein of Neisseria gonorrhoeae and the YdhE protein of Escherichia coli
Nebibe Mutlu et al.
G3 (Bethesda, Md.), 4(7), 1247-1258 (2014-05-09)
Genetic and microscopic approaches using Saccharomyces cerevisiae have identified many proteins that play a role in mitochondrial dynamics, but it is possible that other proteins and pathways that play a role in mitochondrial division and fusion remain to be discovered.
Mohammad Rabbani et al.
Iranian journal of pharmaceutical research : IJPR, 14(3), 901-906 (2015-09-04)
Lipases are diversified enzymes in their properties and substrate specificity, which make them attractive tools for various industrial applications. In this study, an alkalinethermostable lipase producing bacteria were isolated from soil of different regions of Isfahan province (Iran) and its
Ingebjørg H Nymo et al.
Comparative immunology, microbiology and infectious diseases, 37(3), 195-204 (2014-02-19)
Brucellosis, a worldwide zoonosis, is linked to reproductive problems in primary hosts. A high proportion of Brucella-positive hooded seals (Cystophora cristata) have been detected in the declined Northeast Atlantic stock. High concentrations of polychlorinated biphenyls (PCBs) have also been discovered
Yuxia Zhu et al.
Mycopathologia, 179(1-2), 111-118 (2014-10-18)
This study aimed to determine the clinical characteristics and in vitro susceptibilities of Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis isolates from patients with vulvovaginal candidiasis (VVC). We analysed 63 vaginal C. parapsilosis specimens. After the molecular analyses
Magdalena Kwiatek et al.
Folia microbiologica, 60(1), 7-14 (2014-07-06)
Pseudomonas aeruginosa is an opportunistic pathogen that causes serious infections, especially in patients with immunodeficiency. It exhibits multiple mechanisms of resistance, including efflux pumps, antibiotic modifying enzymes and limited membrane permeability. The primary reason for the development of novel therapeutics
N Yousaf et al.
Clinical and experimental immunology, 180(2), 289-304 (2014-12-30)
Endoplasmic reticulum aminopeptidase 1 (ERAP1) processes peptides for major histocompatibility complex (MHC) class I presentation and promotes cytokine receptor ectodomain shedding. These known functions of ERAP1 may explain its genetic association with several autoimmune inflammatory diseases. In this study, we
Linlin Yin et al.
Genetics, 200(2), 431-441 (2015-04-10)
Determining the mechanism of gene function is greatly enhanced using conditional mutagenesis. However, generating engineered conditional alleles is inefficient and has only been widely used in mice. Importantly, multiplex conditional mutagenesis requires extensive breeding. Here we demonstrate a system for
Saroj Kumar Amar et al.
Toxicology letters, 235(2), 84-95 (2015-03-25)
Sunscreen users have been increased, since excessive sun exposure increased the risk of skin diseases. Benzophenone (BP) and its derivatives are commonly used in sunscreens as UV blocker. Its photosafety is concern for human health. Our study showed the role
Mehdi Vafaye Valleh et al.
Zygote (Cambridge, England), 23(5), 712-721 (2014-09-03)
The effects of the paternal breed on early embryo and later pre- and postnatal development are well documented. Several recent studies have suggested that such paternal effects may be mediated by the paternally induced epigenetic modifications during early embryogenesis. The
Jung Ok Lee et al.
Journal of cellular biochemistry, 116(7), 1401-1410 (2015-02-20)
[6]-Gingerol has been used to control diabetes and dyslipidemia; however, its metabolic role is poorly understood. In this study, [6]-gingerol increased adenosine monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation in mouse skeletal muscle C2C12 cells. Stimulation of glucose uptake by [6]-gingerol
A N Devi et al.
Andrology, 3(4), 685-693 (2015-07-23)
NPHP1, the gene that encodes the protein nephrocystin-1 has been identified to be mutated in Juvenile Nephronophthisis, an autosomal recessive cystic kidney disorder which is the most frequent genetic cause of end-stage renal disease (ESRD) in children and young adults.
Hans-Jörg Schneider
European journal of medicinal chemistry, 43(11), 2307-2315 (2008-04-12)
The possible relation of strength and selectivity of ligand binding to biomacromolecules and its theoretical limitation is discussed and illustrated with some examples. It is shown that a linear correlation between selectivity and affinity may be expected on the basis
J Z Phoku et al.
Acta tropica, 140, 158-165 (2014-09-07)
Houseflies are the commonest insects which have increasingly overcrowded human dwellings, particularly in rural areas and constitute a health hazard. In the environment they move back and forth by feeding and breeding on food commodities and filth. This may lead
Irina Tatiana Jovel et al.
Antimicrobial agents and chemotherapy, 59(2), 872-879 (2014-11-26)
In 2008, artemether-lumefantrine was introduced in Guinea-Bissau, West Africa, but quinine has also been commonly prescribed for the treatment of uncomplicated Plasmodium falciparum malaria. An efficacious high-dose chloroquine treatment regimen was used previously. Temporal and seasonal changes of genetic polymorphisms
Kunal Sikder et al.
Food & function, 5(6), 1294-1303 (2014-04-20)
The present study demonstrates for the first time the protective role of two common flavonoids, quercetin and its glycone rutin, against high cholesterol diet (2%) induced hepatotoxicity and inflammation. Swiss albino mice were given either a standard laboratory diet (control)
Genovefa Kolovou et al.
Genetics and molecular biology, 38(2), 129-137 (2015-08-15)
In this work, we examined the impact of polymorphism in the cytochrome P450 (CYP) 3A5 gene, CYP3A5*1 (6986A > G, rs 776746), on the reduction in the lipid levels caused by simvastatin and atorvastatin. We studied 350 hyperlipidemic patients who
Xuan Zhao et al.
Oncotarget, 6(8), 5582-5596 (2015-02-26)
Anti-apoptotic protein Mcl-1 plays an important role in protecting cell from death in acute myeloid leukemia (AML). The apoptosis blocking activity of Mcl-1 is inhibited by BH3-only protein Noxa. We found that dihydroartemisinin (DHA) and its derivative X-11 are potent
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