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Pharmacology and drug discovery research

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Human Renal Proximal Tubule Epithelial Cells (RPTEC) as an Essential Advanced Model to Express Kidney Drug Transporters and Toxicity
Human renal proximal tubule epithelial cells (RPTECs) are commonly used to predict human renal drug permeability and to investigate drug efflux. We have generated transporter knockout (KO) cell lines using CompoZr® Zinc Finger Nuclease (ZFN) technology in a proprietary renal
Using Human iPS Cell-derived Colon Organoids for Cytotoxicity Screening of Drug Compounds
Human epithelial intestinal colonic organoids can be used as an alternative to Caco-2 drug permeability assays for drug screening and compound toxicity testing.
Comparing Quantitative Viability Bioassays: An Evaluation of MTT, alamarBlue™, and Guava® ViaCount® Methods
This article shows a comparison of the quantitative viability bioassays MTT, alamarBlue™, and Guava® ViaCount®.
Chromatography Profile Analysis of Phosphorothioate Oligonucleotides
The ultimate goal of most antisense research is to develop therapeutic agents for diseases such as diabetes, cancer, and HIV/ AIDS. Phosphorothioate oligonucleotides (commonly referred to as S-oligos) are often the molecules of choice because of their resistance to cellular
Inhibition of Nucleic Acid Synthesis by Antibiotics
Quinolones are a key group of antibiotics that interfere with DNA synthesis by inhibiting topoisomerase, most frequently topoisomerase II (DNA gyrase), an enzyme involved in DNA replication.
Evaluation of the reproducibility of Parallel Artificial Membrane Permeation Assays (PAMPA)
This is a white paper on the Evaluation of the reproducibility of Parallel Artificial Membrane Permeation Assays (PAMPA) using MultiScreen® Filter Plates.
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.
Hit Discovery & Confirmation for Early Drug Discovery
Hit discovery and confirmation allows identification of molecules acting against the target. It requires compound screening assays, depending on the drug target.
Protein Binding Determination - Comparison Study of Techniques & Devices
Comparative analysis of Supel™ BioSPME 96-Pin device with a rapid equilibrium dialysis technique for accuracy of measured values, sample cleanliness, and workflow time in drug protein binding.
3D Cell Culture Tools and Techniques
3D cell culture overview. Learn about 2D vs 3D cell culture, advantages of 3D cell culture, and techniques available to develop 3D cell models
Lipopolysaccharides for Research – Structure, Function & Applications
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
Primary Cell Culture Basics
Overview of primary cells and media usage in biomedical culture applications highlights differences from cell lines.
Phase I Drug Metabolism
Phase I biotransformation reactions increase drug compound polarity, mainly occurring in hepatic circulation.
Antimicrobial Peptides
Ribosomally synthesized antimicrobial peptides are a promising focus in antibiotic research amidst bacterial resistance and emerging infectious diseases.
The Role of Liver Transporters in Drug-Drug Interactions
Oral drug delivery involves dissolution in the small intestine and absorption across the enterocyte barrier into the portal vein followed by subsequent delivery through the liver into the systemic circulation.
Membrane Integrity Test for Lipid-PAMPA Artificial Membranes
This is a protocol for a Membrane Integrity test for Lipid-PAMPA Artificial Membranes
Drug transport assays in a 96-well system: reproducibility and correlation to human absorption
Application note on Drug transport assays in a 96-well system using Millicell-96 System from Millipore.
ADCC Assay Using BioIVT Cryopreserved NK Cells
ADCC assay performance and reproducibility using ready-to-use, cryopreserved NK effector cells, A549 target cells expressing a luciferase reporter gene, and anti-EGFR antibody.
The Role of Intestinal Efflux Transporters In Drug Absorption
We presents an article on The Role of Intestinal Efflux Transporters In Drug Absorption.
Caco-2 Intestinal Drug Transporter Models for More Predictive Drug Absorption
Utilize these Caco-2 cell based assay tools for screening small molecule drug compounds prior to clinical studies and submission to regulatory agencies.
Unnatural Amino Acids for Peptide Synthesis
Unnatural amino acids, the non-proteinogenic amino acids that either occur naturally or are chemically synthesized, are becoming more and more important as tools for modern drug discovery research.
Famciclovir Tablets USP Monograph Method Using a Purospher™ STAR RP-8 endcapped HPLC Column and UV Detection
Following the new USP monograph for Famciclovir Tablets, Purospher™ STAR RP-8 endcapped HPLC columns can be used to monitor organic impurities in Famciclovir tablet formulations. Famciclovir is an antiviral drug indicated for the treatment of herpes zoster, herpes simplex virus
Discover Bioactive Small Molecules for Gene Regulation
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
3D Organoid Culture: New In Vitro Models of Development and Disease
Organoid culture products to generate tissue and stem cell derived 3D brain, intestinal, gut, lung and cancer tumor organoid models.
Permeability & Solubility Analysis Workflow
Combining solubility & PAMPA assays streamlines drug permeability testing.